ARG30182
AMPK-ACC pathway Antibody Panel
Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
参考文献9
内含物
| 货号 | 内含物名称 | 宿主克隆性 | 反应 | 应用 | 包装 |
|---|---|---|---|---|---|
| ARG51172 | anti-AMPK alpha 1 / 2 antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG51678 | anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG51853 | anti-Acetyl CoA carboxylase 1 phospho (Ser79) antibody | Rabbit pAb | Hu | WB | 50 μl |
| ARG65351 | Goat anti-Rabbit IgG antibody (HRP) | Goat pAb | Rb | ELISA, IHC-P, WB | 50 μl |
概述
| 产品描述 | AMP-activated protein kinase (AMPK) responds to hormonal and nutrient signals in the central nervous system and peripheral tissues, modulating food intake and whole-body energy homeostasis. The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia and ischemia. Phosphorylates AMPKα1/2 at Thr172/Thr174 in the activation loop and this phosphorylation is required for AMPK activation. . In its activated state, AMPK phosphorylates serine residues 79, 1,200, and 1,215 of acetyl-coenzyme A carboxylase (ACC) which is reducing the activity of ACC. ACC is a potential target of anti-obesity drugs. Carling, D. (2004) Trends Biochem Sci 29, 18-24. Lizcano, J.M. et al. (2004) EMBO J 23, 833-43. Woods, A. et al. (2003) J Biol Chem 278, 28434-42. Levert, K.L. et al. (2002) J Biol Chem 277, 16347-50. Warden, S.M. et al. (2001) Biochem J 354, 275-83. |
|---|---|
| 靶点名称 | AMPK-ACC pathway |
| 別名 | AMPK-ACC pathway antibody; AMPK alpha 1/2 antibody; AMPK alpha 1/2 phospho (Thr183 / Thr172) antibody; Acetyl CoA carboxylase 1 phospho (Ser79) antibody |
属性
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 全名 | Antibody Panel for AMPK-ACC pathway |
|---|---|
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
检测图片 (15) Click the Picture to Zoom In
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ARG51172 anti-AMPK alpha 1 / 2 antibody IHC-P image
Immunohistochemistry: Human brain stained with ARG51172 anti-AMPK alpha 1 / 2 antibody.
From Wang J et al. J Neuropathol Exp Neurol. (2023), doi: 10.1093/jnen/nlad094, Fig. 1.
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ARG51678 anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody IHC-P image
Immunohistochemistry: GBM stained with ARG51678 anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody.
From Xiong J et al. Preprint- (2021), doi: 10.1021/acsomega.0c05399, Fig. 5. E.
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ARG51172 anti-AMPK alpha 1 / 2 antibody WB image
Western blot: Human granulosa stained with ARG51172 anti-AMPK alpha 1 / 2 antibody and ARG51678 anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody.
From Wang Z et al. Phytomedicine- (2021), doi: 10.1016/j.phymed.2021.153654, Fig. 3. C.
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ARG51172 anti-AMPK alpha 1 / 2 antibody WB image
Western blot: Mouse heart stained with ARG51172 anti-AMPK alpha 1 / 2 antibody.
From Wang P et al. Biol Direct. (2024), doi: 10.1186/s13062-024-00505-x, Fig. 5. A.
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ARG51678 anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody WB image
Western blot: C2C12 myotubes stained with ARG51678 anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody.
From Fu WC et al. Food & nutrition research- (2021), doi: 10.29219/fnr.v65.4527, Fig. 2.
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ARG51172 anti-AMPK alpha1/AMPK alpha2 antibody WB image
Western Blot: extracts from A549, HepG2 and 3T3 cells stained with anti-AMPK alpha1/AMPK alpha2 antibody ARG51172.
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ARG51678 anti-AMPK alpha 1 / AMPK alpha 2phospho (Thr183/Thr172) antibody WB image
Western Blot: extracts from C2C12 cells, treated with serum or calf intestinal phosphatase (CIP), stained with anti-AMPK alpha 1 / AMPK alpha 2(phospho Thr174/Thr172) antibody ARG51678.
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ARG51853 anti-Acetyl-CoA Carboxylase phospho (Ser79) antibody WB image
Western Blot: extracts from 293 cells untreated or treated with AICAR stained with anti-Acetyl-CoA Carboxylase (phospho Ser79) antibody ARG51853.
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ARG51678 anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody WB image
Western blot: U87 MG stained with ARG51678 anti-AMPK alpha 1 phospho (Thr183) + AMPK alpha 2 phospho (Thr172) antibody.
From Xiong J et al. Preprint- (2021), doi: 10.1021/acsomega.0c05399, Fig. 4.
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ARG65351 Goat anti-Rabbit IgG antibody (HRP) WB image
Western blot: Human hepatic stellate cell stained with ARG20531 anti-BiP / GRP78 antibody, ARG54938 anti-Caspase 3 antibody, ARG55123 anti-Calreticulin antibody, ARG55177 anti-Caspase 12 antibody, and ARG65683 anti-beta Actin antibody. Secondary Antibody stained with ARG65351 Goat anti-Rabbit IgG antibody (HRP).
From DAI Linyu et al. Journal of Third Military Medical University (2021), doi: 10-16016-j-1000-5404-202012010, Fig. 4.
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ARG51172 anti-AMPK alpha1/AMPK alpha2 antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-AMPK alpha1/AMPK alpha2 antibody ARG51172 (left) or the same antibody preincubated with blocking peptide (right).
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ARG51172 anti-AMPK alpha1/AMPK alpha2 antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-AMPK alpha1/AMPK alpha2 antibody ARG51172.
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ARG51678 anti-AMPK alpha 1 / AMPK alpha 2phospho (Thr183/Thr172) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human lung carcinoma tissue, stained with anti-AMPK alpha 1 / AMPK alpha 2(phospho Thr174/Thr172) antibody ARG51678).
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ARG51172 anti-AMPK alpha 1/2 antibody WB image
Western blot: 30 µg of A549, HepG2, and Mouse liver cell line lysates stained with ARG51172 anti-AMPK alpha 1/2 antibody at 1:500 dilution.
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ARG65351 Goat anti-Rabbit IgG antibody (HRP) WB image
Western blot: Rat placental stained with ARG57589 anti-MTNR1A antibody at 1:1000 dilution, ARG65351 Goat anti-Rabbit IgG antibody (HRP) at 1:5000 dilution.
From Jinzhi Li et al. J Reprod Immunol. (2023), doi: 10.1016/j.jri.2023.104166, Fig. 2.B.
文献引用
The Therapeutic Potential of Exosomes vs. Matrix-Bound Nanovesicles from Human Umbilical Cord Mesenchymal Stromal Cells in Osteoarthritis Treatment
ARG65351; WB /
Environmental acidification drives inter-organ energy mobilization to enhance reproductive performance in medaka (Oryzias latipes)
ARG65351; WB /
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway
ARG51172: WB / Mouse
Expression, clinicopathological significance, and prognostic potential of AMPK, p-AMPK, PGC-1α, and TFAM in astrocytomas
ARG51172: IHC-P / Human
The role of CD36-Fabp4-PPARγ in skeletal muscle involves insulin resistance in intrauterine growth retardation mice with catch-up growth
ARG51172: WB / Mouse
Berberine improves ovulation and endometrial receptivity in polycystic ovary syndrome.
ARG51172, ARG51678: WB / Human
Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes
ARG51678: WB / Mouse
Amlexanox Enhances Temozolomide-Induced Antitumor Effects in Human Glioblastoma Cells by Inhibiting IKBKE and the Akt-mTOR Signaling Pathway
ARG51678: WB, IHC-P / Human
Amlexanox Enhances Temozolomide-Induced Anti-Tumor Effects In Human Glioblastoma Cells By Inhibiting Ikbke And The Akt-mtor Signaling Pathway.
ARG51678: WB, IHC-P / Human
