Neuroinflammation in PD: a Multiplex ELISA approach

arigo is proud to announce that arigoPLEX^® Inflammatory Cytokine Multiplex ELISA Kit was used to study Parkinson's disease (PD)-associated neuroinflammation and was cited in J Neuroinflammation.

Kurniawan et al. examined the contribution of LRRK2-G2019S mutation to microglial neurotoxicity using PD patient-derived iPSC models. The authors used arigoPLEX^® Multiplex ELISA Kit to analyze the inflammatory cytokines secreted by LRRK2-G2019S mutant microglia. They found that LRRK2-G2019S mutant microglia showed elevated TNF-α secretion, thereby driving neuroinflammation.

Kurniawan et al., (2025) J Neuroinflammation. 22(1):244.

arigoPLEX^® Inflammatory Cytokine Multiplex ELISA Kits

Benefits

● Concurrent measurement of 4 or 8 factors

● Quantifying cytokines at pg/mL range

● Single detection reagent

● Measured by ELISA reader at OD 450 nm

4-in-1 kits

IL-1β, IL-6, TNF-α, IFN-γ

ARG82862 for human

ARG82842 for mouse

8-in-1 kit

GM-CSF, IL-8, MCP-1, IL-1α, IL-1β, IL-6, TNF-α, IFN-γ

ARG83509 for human

Neuroinflammation Antibody Panel (ARG30324)

Benefits

● Includes microglial markers Iba1 and CD68 antibodies

● Includes astrocyte marker GFAP antibody

● Ideal for triple staining

● Works on human, mouse and rat samples

Microglia markers

Iba1 antibody (ARG67006)

Mouse mAb

Iba1 antibody (ARG11062)

Rabbit pAb

Iba1 antibody (ARG63338)

Goat pAb

Coronin 1 antibody (ARG10711)

Rabbit pAb

CD68 antibody [KP1] (ARG10514)

Mouse mAb

F4/80 antibody [Cl:A3-1] (ARG22476)

Rat mAb