ARG55256
anti-IL17 / IL17A antibody
anti-IL17 / IL17A antibody for Western blot and Human
Cancer antibody; Immune System antibody
参考文献5
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL17 / IL17A |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL17 / IL17A |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human IL17A (NP_002181.1). |
| 偶联标记 | Un-conjugated |
| 別名 | IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat liver and Mouse liver. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL17A |
| 全名 | interleukin 17A |
| 背景介绍 | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt] |
| 产品亮点 | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Rabbit IgG secondary antibodies; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 |
| 研究领域 | Cancer antibody; Immune System antibody |
| 预测分子量 | 18 kDa |
| 翻译后修饰 | Found both in glycosylated and nonglycosylated forms. |
检测图片 (4) Click the Picture to Zoom In
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ARG55256 anti-IL17 / IL17A antibody IHC-P image
Immunohistochemistry: Mouse colons stained with ARG55256 anti-IL17 / IL17A antibody.
From Yu-Lung Chang et al. Journal of Medical and Biological Engineering- (2019), doi: 10-1007-s40846-019-00494-7, Fig. 5.
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ARG55256 anti-IL17 / IL17A antibody WB image
Western blot: Mouse intestine stained with ARG21502 anti-IFN gamma antibody [XMG1.2], ARG56667 anti-IL1 alpha antibody, ARG56625 anti-IL6 antibody, ARG55256 anti-IL17 / IL17A antibody, ARG10158 anti-TNF alpha antibody [2C8], ARG21475 anti-IL10 antibody [JES5-2A5], ARG10002 anti-TGF beta antibody [TB21], ARG54674 anti-CXCR4 antibody and ARG54150 anti-STAT3 antibody.
From Yu H et al. Front Microbiol. (2023), doi: 10.3389/fmicb.2023.1126808, Fig. 4. B.
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ARG55256 anti-IL17 / IL17A antibody WB image
Western blot: 25 µg of Rat liver and Mouse liver lysates stained with ARG55256 anti-IL17 / IL17A antibody at 1:1000 dilution.
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ARG55256 anti-IL17 / IL17A antibody WB image
Western blot: Extracts of normal (lane 1), retinopathy of prematurity (lane 2) and VEGF/rho transgenic mice (lane 3) stained with ARG55256 anti-IL17 / IL17A antibody.
Expected signal was at 18 kDa, and the 36 kDa signal in figure might be dimer form of IL17 protein.
文献引用
ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression
WB / Human
Fecal microbiota transplantation inhibits colorectal cancer progression: Reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses
WB / Mouse
Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling.
IHC-P / Human
Therapeutic Efficacy of Subcutaneous and Intraperitoneal Injections of a Single Dose of Human Umbilical Mesenchymal Stem Cells in Acute and Chronic Colitis in a Mouse Model.
IHC-P / Mouse
Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells.
IHC-P / Human
