ARG55256

anti-IL17 / IL17A antibody

anti-IL17 / IL17A antibody for Western blot and Human

Cancer antibody; Immune System antibody
publication_link 参考文献5

概述

产品描述

Rabbit Polyclonal antibody recognizes IL17 / IL17A

反应物种 Hu
应用 WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 IL17 / IL17A
抗原物种 Human
抗原 Recombinant protein of Human IL17A (NP_002181.1).
偶联标记 Un-conjugated
別名 IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8

应用说明

应用建议
应用 推荐稀释比
WB1:500 - 1:1000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Rat liver and Mouse liver.

属性

形式 Liquid
纯化 Affinity purification with immunogen.
缓冲液 PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 3605 Human IL17A

Swiss-port # Q16552 Human Interleukin-17A

基因名称 IL17A
全名 interleukin 17A
背景介绍 The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
生物功能 Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt]
产品亮点 Related products:
IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Rabbit IgG secondary antibodies;
Related news:
HMGB1, a biomarker and therapeutic target in COVID-19
研究领域 Cancer antibody; Immune System antibody
预测分子量 18 kDa
翻译后修饰 Found both in glycosylated and nonglycosylated forms.

检测图片 (2) Click the Picture to Zoom In

  • ARG55256 anti-IL17 / IL17A antibody WB image

    Western blot: 25 µg of Rat liver and Mouse liver lysates stained with ARG55256 anti-IL17 / IL17A antibody at 1:1000 dilution.

  • ARG55256 anti-IL17 / IL17A antibody WB image

    Western blot: Extracts of normal (lane 1), retinopathy of prematurity (lane 2) and VEGF/rho transgenic mice (lane 3) stained with ARG55256 anti-IL17 / IL17A antibody.

    Expected signal was at 18 kDa, and the 36 kDa signal in figure might be dimer form of IL17 protein.

文献引用

ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression

WB / Human

Rongrong Tang et al.
Cell Mol Biol (Noisy-le-grand).,  (2023)

publication_link

 

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Fecal microbiota transplantation inhibits colorectal cancer progression: Reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses

WB / Mouse

Hao Yu et al.
Front Microbiol.,  (2023)

publication_link

 

hr_line

Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling.

IHC-P / Human

Junli Zhang et al.
Ann Transl Med.,  (2020)

publication_link

 

hr_line

Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells.

IHC-P / Human

Li Sen et al.
J Exp Clin Cancer Res.,  (2019)

publication_link

 

hr_line

Therapeutic Efficacy of Subcutaneous and Intraperitoneal Injections of a Single Dose of Human Umbilical Mesenchymal Stem Cells in Acute and Chronic Colitis in a Mouse Model.

IHC-P / Mouse

Chang Yu‑Lung et al.
Journal of Medical and Biological Engineering.,  (2019)

publication_link

 

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