CTL/NK Activation Multiplex ELISA Kit is launched

CTL/NK Activation Multiplex ELISA Kit is launched

Cytotoxic T cells (CTLs) and Natural Killer (NK) cells are cytotoxic lymphocytes critical to immune system and are the key players to eliminate cancer cells. Upon activation, CTLs and NK cells recognize cancer cells and secrete pore forming protein Perforin and proteases Granzymes that trigger apoptosis and pyroptosis, leading to cancer cell death. Granzymes and perforin are markers of anti-tumor cytotoxicity. In addition, activated CTLs and NK cells secrete chemokines, especially IFN-γ and TNFα, which promote anti-cancer function.

However, immune checkpoints and immunosuppressive microenvironment suppress CTL and NK cell activity and thus inhibit anti-tumor immunity. To develop immune checkpoint inhibitors and enhance anti-tumor immune responses by targeting immunosuppressive cells such as Treg, TAMs, and MDSCs are emerging strategies in immunotherapy. In recent years, chimeric antigen receptor (CAR)-T and CAR-NK cell therapies have moved into the spotlight as a powerful tool for immunotherapy.

arigo is proud to introduce the newly launched Human CTL/NK Activation Multiplex ELISA Kit (ARG83005) which is the best solution to examine the activation of CTLs and NK cells as well as assess the efficacy of immunotherapy.




● Concurrent measurement of 4 factors
   Cytotoxicity - Granzyme B, Perforin
   CTL/NK activation - IFN-γ, TNF-α

● High sensitivity for quantification at pg/mL levels
● Validated on serum, plasma, and cell culture supernatant
● Less sample volumes and assay time required

GrzB - 15.63 pg/ml
Perforin - 93.75 pg/ml
IFN-γ - 7.8 pg/ml
TNF-α - 22.44 pg/ml



▶  arigoPLEX® Multiplex ELISA Kits

multiplex ELISA kit

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ELISA analysis

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