ARG53372

anti-iNOS antibody [SP126]

anti-iNOS antibody [SP126] for IHC-Formalin-fixed paraffin-embedded sections and Human

Inflammation Study antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M1 macrophage Marker antibody

概述

产品描述 Rabbit Monoclonal antibody [SP126] recognizes iNOS
反应物种 Hu
预测物种 Ms, Rat
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SP126
同位型 IgG
靶点名称 iNOS
抗原物种 Human
抗原 Synthetic peptide near the C-terminus of mouse iNOS protein.
偶联标记 Un-conjugated
別名 HEP-NOS; Inducible NO synthase; INOS; Nitric oxide synthase, inducible; iNOS; Hepatocyte NOS; NOS2A; Peptidyl-cysteine S-nitrosylase NOS2; Inducible NOS; NOS; NOS type II; EC 1.14.13.39

应用说明

应用建议
应用 推荐稀释比
IHC-P1:100
应用说明 IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Incubation Time: 10 min at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Lung

属性

形式 Liquid
纯化 Purified by protein A/G
缓冲液 PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide
抗菌剂 < 0.1% Sodium azide
稳定剂 1% BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 4843 Human NOS2

Swiss-port # P35228 Human Nitric oxide synthase, inducible

基因名称 NOS2
全名 nitric oxide synthase 2, inducible
背景介绍 iNOS: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide synthase is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
生物功能 iNOS produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109). [UniProt]
细胞定位 Cytoplasm
产品亮点 Related products:
iNOS antibodies; iNOS ELISA Kits; iNOS Duos / Panels; Anti-Rabbit IgG secondary antibodies;
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研究领域 Inflammation Study antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M1 macrophage Marker antibody
预测分子量 131 kDa

检测图片 (2) Click the Picture to Zoom In

  • ARG53372 anti-Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] IHC-P image

    Immunohistochemistry: Human Lung stained with Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] (ARG53372)

  • ARG53372 anti-Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] IHC-P image

    Immunohistochemistry: Human Lung stained with Nitric Oxide Synthase-Inducible (iNOS) antibody [SP126] (ARG53372)

克隆号文献

Expression and prognostic significance of iNOS in uveal melanoma.

IHC / Human

Johansson CC et al.
Int J Cancer.,  (2010)

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