ARG63064

anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC)

anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC) for Depletion,Flow cytometry,IHC-Frozen sections and Mouse

Mouse Inflammatory Cell Marker antibody; Neurophil Marker antibody; Mouse MDSC Marker antibody; Myeloid-derived suppressor cell antibody

概述

产品描述 FITC-conjugated Rat Monoclonal antibody [RB6-8C5] recognizes Ly6G + Ly6C
反应物种 Ms
预测物种 Hu, Rat, Mk
应用 Depletion, FACS, IHC-Fr
特异性 This antibody recognizes the mouse Gr-1 antigen, a ~21 - 25 kDa GPI anchored cell surface protein bearing a single uPAR/Ly6 domain that belongs to the Ly-6 family of proteins (Lee et al. 2013). Clone RB6-8C5 reacts predominantly with the Ly-6G protein but weaker reactivity with the Ly-6C protein has been reported (Fleming et al. 1993). However, other observations dispute the cross-reactivity of clone RB6-8C5 with the Ly-6C protein with the alternative explanation that certain sub-populations of bone marrow cells simultaneously express both Ly-6C and Ly-6G (Nagendra et al. 2007).
宿主 Rat
克隆 Monoclonal
克隆号 RB6-8C5
同位型 IgG2b, kappa
靶点名称 Ly6G + Ly6C
抗原物种 Mouse
偶联标记 FITC
別名 Gr1; Gr-1; Ly-6G

应用说明

应用建议
应用 推荐稀释比
DepletionAssay-dependent
FACS< 1 µg/10^6 cells
IHC-FrAssay-dependent
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
缓冲液 PBS and 0.1% Sodium azide.
抗菌剂 0.1% Sodium azide
浓度 0.5 mg/ml
存放说明 Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 546644 Mouse Ly6g

基因名称 Ly6g
全名 lymphocyte antigen 6 complex, locus G
背景介绍 Ly6G is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. Ly6G is a good marker for detection of peripheral neutrophils. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. Physiological role of Ly6G remains still unclear. Its treatment with antibodies in vivo leads to neutropenia and has inhibitory effect on local immune responses. _x000D_
产品亮点 Related products:
Ly6 antibodies; Ly6 ELISA Kits; Ly6 Duos / Panels; Anti-Rat IgG secondary antibodies;
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研究领域 Mouse Inflammatory Cell Marker antibody; Neurophil Marker antibody; Mouse MDSC Marker antibody; Myeloid-derived suppressor cell antibody
预测分子量 12 kDa

检测图片 (3) Click the Picture to Zoom In

  • ARG63064 anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC) FACS image

    Flow Cytometry: BALB/c Mouse bone marrow cells stained with ARG20804 anti-CD106 / VCAM1 antibody [M/K-2] (PE) and ARG63064 anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC).

  • ARG63064 anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC) FACS image

    Flow Cytometry: BALB/c Mouse bone marrow cells stained with ARG21049 anti-CD117 / c-Kit antibody [2B8] (PE) and ARG63064 anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC).

  • ARG63064 anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC) FACS image

    Flow Cytometry: BALB/c Mouse bone marrow cells stained with ARG63064 anti-Ly6G + Ly6C antibody [RB6-8C5] (FITC) and ARG20852 anti-CD19 antibody [6D5] (PE).

克隆号文献

Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.

Deroost K et al.
PLoS One.,  (2014)

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The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.

Caruso JA et al.
Oncogene.,  (2015)

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Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension.

IHC-P / Mouse

Ohm IK et al.
PLoS One.,  (2014)

publication_link

 

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Alterations in neutrophil production and function at an early stage in the high-fructose rat model of metabolic syndrome.

Tagzirt M et al.
Am J Hypertens.,  (2014)

publication_link

 

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Statins prevent cervical remodeling, myometrial contractions and preterm labor through a mechanism that involves hemoxygenase-1 and complement inhibition.

Gonzalez JM et al.
Mol Hum Reprod.,  (2014)

publication_link

 

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Intestinal epithelial CD98 directly modulates the innate host response to enteric bacterial pathogens.

ICC/IF / Mouse

Charania MA et al.
Infect Immun.,  (2013)

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Density of Gr1-positive myeloid precursor cells, p-STAT3 expression and gene expression pattern in canine mammary cancer metastasis.

IHC-P / Dog

Król M et al.
Vet Res Commun.,  (2011)

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Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

FACS / Mouse

Chen D et al.
J Exp Med.,  (2008)

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