ARG40797
anti-GDF9 antibody
anti-GDF9 antibody for Western blot and Human,Mouse,Rat
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GDF9 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GDF9 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 205-454 of Human GDF9 (NP_005251.1). |
| 偶联标记 | Un-conjugated |
| 別名 | GDF-9; Growth/differentiation factor 9 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | 293T | ||||
| 实际分子量 | 50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GDF9 |
| 全名 | growth differentiation factor 9 |
| 背景介绍 | This gene encodes a member of the transforming growth factor-beta superfamily. The encoded preproprotein is processed into a secreted factor that is required for ovarian folliculogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| 生物功能 | Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG40797 anti-GDF9 antibody WB image
Western blot: Human GCs stained with ARG10002 anti-TGF beta antibody [TB21] , ARG40797 anti-GDF9 antibody, ARG54155 anti-Caspase 9 antibody, ARG56357 anti-BMP15 antibody, ARG66671 anti-Caspase 3 (cleaved) antibody and ARG66247 anti-Bax antibody [SQab1736].
From Liang Y et al. Gynecol Endocrinol. (2023), doi: 10.1080/09513590.2023.2181652, Fig. 3.
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ARG40797 anti-GDF9 antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG40797 anti-GDF9 antibody at 1:3000 dilution.
文献引用
Resveratrol improves ovarian state by inhibiting apoptosis of granulosa cells
WB / Human
