Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

ARG10112; WB / Human, Mouse

Su H et al.
Nat Commun,  (2025)

Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells

ARG10112: WB / Human

Li-Xian Yang et al.
Nat Commun.,  (2025)

KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease

ARG10112: WB / Human, Mouse

Maoju Wang et al.
Aging Cell.,  (2025)

Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer's disease

ARG10112; WB / Mouse

Xia L et al.
Sci Adv,  (2025)

The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I

ARG10112: WB / Mouse

Junjun Quan et al.
pre-print,  (2024)

Expression and correlation of Surfeit 4 gene in esophageal squamous cell carcinoma

ARG65350; WB / 

Jun‑xing Liu et al.
Holistic Integrative Oncology,  (2024)

PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation

ARG10112: WB / Human, Mouse

Mingliang Xu et al.
Exp Neurol.,  (2024)

Environmental acidification drives inter-organ energy mobilization to enhance reproductive performance in medaka (Oryzias latipes)

ARG65350; WB / 

Hsin-Ju Chuang  et al.
J Hazard Mater.,  (2024)

Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro

ARG10112: WB / Mouse, Rat

Zhenyu Feng et al.
Biomed Pharmacother.,  (2024)

Shionone relieves oxygen-glucose deprivation/reoxygenation induced SH-SY5Y cells injury by inhibiting the p38 MAPK/NF-κB pathway

ARG10112: WB / Human

Xiaoli Zhou et al.
J Cardiothorac Surg,  (2024)

7,8-Dihydroxyflavone ameliorates cognitive impairment induced by repeated neonatal sevoflurane exposures in mice through increasing tau O-GlcNAcylation

ARG10112: WB / Mouse

Mingliang Xu et al.
Neurosci Lett.,  (2024)

Uric acid mitigates cognitive deficits via transcription factor EB - mediated microglial autophagy in mice models of Alzheimer's disease

ARG10112: WB / Mouse

Qian Xiao et al.
,  (2023)

黄芪甲苷预处理对大鼠肠缺血再灌注所致肺损伤的影响及其机制

ARG10112: WB / Rat

王蕾 et al.
中国中西医结合外科杂志,  (2023)

Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases

ARG10112: WB / Mouse

Zhiqi Feng et al.
J Med Chem.,  (2023)

PPARγ activation suppresses chondrocyte ferroptosis through mitophagy in osteoarthritis

ARG10112: WB / Rat

Xiang Xue et al.
J Orthop Surg Res.,  (2023)

Resveratrol inhibits Toxoplasma gondii-induced lung injury, inflammatory cascade and evidences of its mechanism of action

ARG10112: WB / Mouse

Yu Nan Lu et al.
Phytomedicine.,  (2023)

Knockdown of Porf-2 restores visual function after optic nerve crush injury

ARG10112: WB / Mouse

Di Chen et al.
Cell Death Dis.,  (2023)

KDF1 Promoted Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells through Activating STAT3 and AKT Pathway

ARG65350: WB / 

Yi-Qing Guo et al.
Biomedicines.,  (2023)

SCM-198 Prevents Endometriosis By Reversing Low Autophagy Levels Of Endometriotic Stromal Cells Via Inhibiting TNF-Α-Aromatase-Estrogen-Erα Pathway And Promoting PR Expression

ARG10122: WB / Human

Yikong Lin et al.
Research Square,  (2022)

SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell via Balancing ERα and PR Signals

ARG10112: WB / Mouse

Yi-Kong Lin  et al.
Front Endocrinol (Lausanne),  (2022)

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice

ARG10112: WB / Mouse

Binbin Cui  et al.
Front Pharmacol,  (2022)

Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model

ARG10112: WB / Pig

Jianni Huang et al.
Frontiers in Cell and Developmental Biology,  (2022)

Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice

ARG10112: WB / Mouse

Junjie Li et al.
Genes & Diseases,  (2022)

Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury

ARG10112: WB / Human

Yuhua Zhou et al.
Cent Eur J Immunol .,  (2022)

Genetic labeling reveals cellular expression pattern of neuregulin 1 in mouse forebrain

ARG10112: WB / Human

Chen-Yun Ding et al.
Research square,  (2022)

Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis

ARG10112: WB / Human

QIAN Ming et al.
 Chinese Journal of Natural Medicines ,  (2022)

Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation

ARG65681: IHC-P / Mouse

Zhenyu Tian et al.
Cell Host Microbe,  (2022)

Structural Basis of VSIG3: The Ligand for VISTA.

ARG10112: WB / Human

Xiaoxue Xie et al.
Front Immunol.,  (2021)

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits.

ARG10112: WB / Human

Yi-An Chen et al.
Biomedicines.,  (2021)

Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

ARG10112: WB / Rat

Lu Yang et al.
Korean J Physiol Pharmacol.,  (2021)

The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis.

ARG10112: WB / Human

Huey-Jiun Ko et al.
Biomolecules.,  (2021)

Decidual NR2F2-Expressing CD4 + T Cells Promote TH2 Transcriptional Program During Early Pregnancy.

ARG65350: WB / 

Yikong Lin et al.
Front Immunol.,  (2021)

Evaluation of Class IIa Histone Deacetylases Expression and In Vivo Epigenetic Imaging in a Transgenic Mouse Model of Alzheimer's Disease

ARG10112: WB / Human

Yi-An Chen et al.
Int J Mol Sci.,  (2021)

7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson's disease

ARG10112: WB / Mouse

Li Zuo et al.
Cell Death Discov.,  (2021)

M351-0056 is a novel low MW compound modulating the actions of the immune-checkpoint protein VISTA.

ARG10112: WB / Human, Mouse

Xinlei Hu et al.
Br J Pharmacol.,  (2021)

MicroRNA-145 Delay Plaque Erosion by Down-Regulating TGFβr Ii and Suppressing Autophagy of Vascular Smooth Muscle Cells.

ARG65350: WB / 

Yunjuan Jiao et al.
Preprint.,  (2021)

Cardiac-Specific Gene TNNI3 as a Potential Oncogene for Kidney Cancer and Its Involvement in Wnt Signaling Pathway.

ARG10112: WB / Human

Weian Zhao et al.
Preprint.,  (2021)

Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis.

ARG10112: WB / Human

Jing Wang et al.
Arch Oral Biol.,  (2021)

Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.

ARG65350: WB / Mouse

Yajie Chen et al.
Proc Natl Acad Sci.,  (2021)

Excessive fibroblast growth factor 23 promotes renal fibrosis in mice with type 2 cardiorenal syndrome.

ARG10112: WB / Mouse, Rat

Huixin Hao et al.
Aging (Albany NY).,  (2021)

Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.

ARG65350: WB / Mouse

Er-Jun Hao et al.
J Med Chem.,  (2021)

Blocking the CCL5-CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells.

ARG65350: WB / Mouse

Yuan Zhuang et al.
J Hepatocell Carcinoma.,  (2021)

Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid

ARG10112: WB / Human

Liu Liu et al.
Eur J Med Chem .,  (2021)

Intermittent pressure imitating rolling manipulation ameliorates injury in skeletal muscle cells through oxidative stress and lipid metabolism signalling pathways.

ARG65350: WB / Mouse

Li-Juan Zhao et al.
Gene.,  (2021)

Repurposing the FDA-approved anticancer agent ponatinib as a fluconazole potentiator by suppression of multidrug efflux and Pma1 expression in a broad spectrum of yeast species.

ARG65350: WB / Mouse

Lin Liu et al.
Microb Biotechnol.,  (2021)

Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development

ARG65350: WB / 

Shanshan Wang et al.
Genes Dis.,  (2020)

ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17.

ARG10112: WB / Mouse

Chia-Wei Lin et al.
Neurosci Lett.,  (2020)

Codelivery of Anti-PD-1 Antibody and Paclitaxel with Matrix Metalloproteinase and pH Dual-Sensitive Micelles for Enhanced Tumor Chemoimmunotherapy.

ARG65350: WB, IHC-P / 

Su Zhenwei et al.
Small.,  (2020)

SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury

ARG10112, ARG65350: WB / Human, Mouse, Rat

Bingzheng Lu et al.
Oxid Med Cell Longev.,  (2020)

miR-765 Impairs Pancreatic β-cell Function by Targeting PDX1 in type 2 Diabetes.

ARG65350: WB / 

Li Zheng et al.
Preprint.,  (2020)

Study of isolation and characterization of extracellular vesicles in senescent tumor cells induced by chemotherapeutics.

ARG10112: WB / Human

Qi Zhou et al.
Chinese Journal of Immunology.,  (2020)

Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice

ARG10112: WB / Mouse

Yuanping Shi et al.
Mol Med Rep.,  (2020)

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I.

ARG10112: WB / Human, Mouse

Geng Sun et al.
Eur J Med Chem.,  (2020)

CLC-3 and SOX2 regulate the cell cycle in DU145 cells

ARG65350: WB / 

Jiahong Chen et al.
Oncol Lett.,  (2020)

High expression of FUSE binding protein 1 in breast cancer stimulates cell proliferation and diminishes drug sensitivity.

ARG65350: WB / 

Liu Wei et al.
Int J Oncol.,  (2020)

Cardiac troponin I R193H mutant interacts with HDAC1 to repress phosphodiesterase 4D expression in cardiomyocytes

ARG10112: WB / Mouse

Weian Zhao et al.
Genes Dis.,  (2020)

Prokaryotic expression and immunogenicity analysis of Clostridium difficile binary toxin A.

ARG65350: WB / Mouse

Huang Yingfeng et al.
检验医学 (Laboratory Medicine),  (2020)

BCL7C suppresses ovarian cancer growth by inactivating mutant p53.

ARG65350: WB / 

Canhua Huang et al.
J Mol Cell Biol.,  (2020)

A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells.

ARG65350: WB / Mouse

Li Xie et al.
Nucleic Acids Res.,  (2020)

Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells.

ARG10112: WB / Human

Li Sen et al.
J Exp Clin Cancer Res.,  (2019)

Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain.

ARG10112: WB / Rat

Yu Qing et al.
Brain Struct Funct.,  (2019)

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.

ARG65350: WB, IHC-P / Mouse

Chen Yajie et al.
Cell Death and Disease.,  (2019)

Down-regulation of HTR1A-modulated ACC activation contributes to stress-induced visceral hyperalgesia in rats.

ARG65350: WB / Mouse

Yi Lisha et al.
Neurogastroenterol Motil.,  (2019)

SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways.

ARG10112: WB / Human

Yunyun Li et al.
Acta Biochim Biophys Sin.,  (2019)

Effects of perfluorooctane on the retina as a short-term and small amounts remnant in rabbits.

ARG65350: IHC-P / Mouse

Li Qing-Chen et al.
Int J Ophthalmol.,  (2019)

Epigenetic regulation of phosphodiesterase 4d in restrictive cardiomyopathy mice with cTnI mutations.

ARG10112: WB / Mouse

Zhao Weian et al.
Sci China Life Sci.,  (2019)

Icariin suppresses cell cycle transition and cell migration in ovarian cancer cells.

ARG65350: WB / Mouse

Wang Pengzhen et al.
Oncol Rep.,  (2019)

抗菌肽Sublancin增强小鼠获得性免疫的研究

ARG65350: ELISA / Mouse

张晓雅 et al.
动物营养学报,  (2018)

Treatment of diabetic mice with A Combination of Ketogenic Diet and Aerobic Exercise via modulations of PPARs gene programs.

ARG65350: WB / Mouse

Zhang Qiang et al.
PPAR Research.,  (2018)

AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway.

ARG10112: WB / Rat

Hu Xinlei et al.
Acta Biochim Biophys Sin (Shanghai).,  (2018)

The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs.

ARG10112: WB / Rat

Wu Yao et al.
Korean J Physiol Pharmacol.,  (2018)

Epigallocatechin-3 gallate prevents pressure overload-induced heart failure by up-regulating SERCA2a via histone acetylation modification in mice.

ARG10112: WB / Mouse

Liu Lifei et al.
PLoS One.,  (2018)

MIR4532 gene variant rs60432575 influences the expression of KCNJ11 and the sulfonylureas-stimulated insulin secretion.

ARG65350: WB / Mouse

Chen Zhang-Ren et al.
Endocrine.,  (2018)

Knockdown of LGALS12 inhibits porcine adipocyte adipogenesis via PKA-Erk1/2 signaling pathway

ARG65350: WB / Mouse

Wu Wenjing et al.
Acta Biochim Biophys Sin.,  (2018)

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration.

ARG10112: WB / Human

Xu D et al.
Pharmacol Res.,  (2017)

Cardiac Protection of Valsartan on Juvenile Rats with Heart Failure by Inhibiting Activity of CaMKII via Attenuating Phosphorylation

ARG10112: WB / Rat

Yao Wu et al.
BioMed Research International.,  (2017)

Checking transfer efficiency and equal loading via qualitative optical way in western blotting.

ARG10112: WB / Human

Gong JH et al.
Electrophoresis,  (2017)

Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation.

ARG10112: WB / Mouse

Xie J et al.
Cardiovasc Diabetol.,  (2016)

Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells.

ARG10112: WB / Human

Yao B et al.
Cell Signal.,  (2016)

Study on the inhibition of hyperthermic CO₂ pneumoperitoneum on the proliferation and migration of colon cancer cells and its mechanism.

ARG65350: WB / 

Zhao J et al.
Oncol Rep.,  (2016)