Product Highlight

Product Highlight

arigo offers Antibody Duo and Antibody Panel products for researchers who work on various research topics. Please find arigo’s mini pathway figures featuring our high quality Duos and Panels for your experimental needs!


Apoptosis Pathway

In multicellular organisms, cells no longer needed or have become a threat to the organism will be destroyed by a tightly regulated suicide mechanism called programmed cell death, or more commonly known as Apoptosis.

Apoptosis process involves a cascade of proteolytic cleavage of Caspase molecules. Apoptosis can be initiated by intra- or extracellular death signals and the regulation of apoptosis can involve a wide variety of molecules.

arigo offers Antibody Duos for the study of key stages in Apoptosis regulation.



Product name: Apoptosis Marker Antibody Duo (Caspase 3, PARP)
Cat no: ARG30105

The TUNEL assay has been commonly used as a detection method for identifying apoptotic cells. While useful, it can also yield highly variable results as some non-apoptotic nuclei showing high levels of RNA synthesis/splicing can also be labeled by TUNEL technique.
Cleavage of Caspase 3 and PARP (Poly (ADP-ribose) Polymerase is a pre-requisite for cells who undergo final stage of cell death. The use of anti-cleaved caspase3 (ARG20003) and anti-cleaved PARP (ARG20041) antibodies adds a more specific weapon to the arsenal of techniques for confirming apoptosis in tissue specimens.


GSK3 Downstream Signaling Pathway

Constitutively active GSK-3 acts to destabilize beta catenin through phosphorylation (Ser37), thus, functioning as a tumor suppressor to limit proliferation. In contrast, GSK-3 promotes expansion of leukemic cells transformed by HOX overexpression through phosphorylation of CREB (Ser133) and subsequent formation of a transcriptional coactivator complex. (Cancer Cell 17, June 15, 2010)

arigo provides CREB / beta Catenin phospho Duos, ARG30024, which include beta catenin (phosphor Ser37) antibody and CREB (phosphor Ser133) antibody for researchers to analysis the downstream protein and the pathway of active-GSK-3


Product name: Phospho-CREB (pS133)/Phospho beta-Catenin (pS37) Antibody Duo
Cat no: ARG30024



ARG51556 CREB(pSer133)Antibody

WB: HeLa cells with or without UV treatment.       IHC: Human breast carcinoma tissue.

ARG51710 β Catenin (pSer37) Antibody

WB: HT29 cells with or without peptide blocking.       IHC: Human breast carcinoma tissue.