Hypoxia-induced transcription, histone demethylases are involved

Hypoxia-induced transcription, histone demethylases are involved


Hypoxia (oxygen deficiency) is a contributing factor in many human diseases. Previous studies focused on the role and regulation of hypoxia-inducible factor 1 (HIF-1) in hypoxia-induced gene transcription. Recently, two groups reported that certain histone demethylases also sense the oxygen deficiency and alter gene expression in a HIF-1-independent manner.

Batie et al. and Chakraborty et al. respectively demonstrated that the lysine-specific demethylases KDM5A and KDM6A act as oxygen sensors and directly alter gene expression by changing the chromatin structure.

arigo offer quality hypoxia markers and a series of antibodies against methylated H3 or demethylases to facilitate related research.

Hypoxia markers

HIF-1 alpha antibody (ARG10515)

BNIP3 antibody (ARG58336)

CA9 antibody (ARG57809)


Histone H3 & Lys-methylated H3

Histone H3 antibody (ARG55260)

H3K4me1 antibody (ARG54760)

H3K9me2 antibody (ARG54763)

H3K37me3 antibody

H3 K36M mutant antibody



Histone demethylases

KDM3A antibody (ARG40757)

KDM4A antibody (ARG40756)

KDM5B antibody (ARG59272)

KDM6B antibody (ARG54857)


KDM7A antibody (ARG40753)



Batie et al. (2019) Science. 363(6432):1222-1226. 
Chakraborty et al. (2019) Science. 363(6432):1217-1222.