ARG40753
anti-KDM7A / JHDM1D antibody
anti-KDM7A / JHDM1D antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KDM7A / JHDM1D |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KDM7A / JHDM1D |
| 抗原物种 | Mouse |
| 抗原 | Recombinant fusion protein corresponding to aa. 417-735 of Mouse KDM7A (NP_001028602.2). |
| 偶联标记 | Un-conjugated |
| 別名 | EC 1.14.11.-; Lysine-specific demethylase 7A; Lysine-specific demethylase 7; JHDM1D; JmjC domain-containing histone demethylation protein 1D |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse spleen | ||||
| 实际分子量 | 107 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KDM7A |
| 全名 | lysine (K)-specific demethylase 7A |
| 生物功能 | Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 产品亮点 | Related products: Anti-Rabbit IgG secondary antibodies; Related news: Hypoxia-induced transcription, histone demethylases are involved |
| 预测分子量 | 107 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG40753 anti-KDM7A / JHDM1D antibody WB image
Western blot: 25 µg of Mouse spleen lysate stained with ARG40753 anti-KDM7A / JHDM1D antibody at 1:1000 dilution.
