ARG83110

arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B)

arigoPLEX® Human Gamma Delta T cell multiplex ELISA 试剂盒 (IL8, IL17, IFN-gamma, Granzyme B) for ELISA and Human

概述

产品描述 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B) is an Enzyme Immunoassay kit for the semiquantification of Human Gamma Delta T cell (IL8, IL17, IFN gamma, Granzyme B) in serum, plasma and cell culture supernatants.

See all Multiplex ELISA kits
反应物种 Hu
应用 ELISA
靶点名称 IL8, IL17, IFN gamma, Granzyme B
偶联标记 HRP
偶联标记说明 Substrate: TMB and read at 450 nm.
灵敏度 IL8: 23.4 pg/ml
IL17: 7.8 pg/ml
IFN gamma: 7.8 pg/ml
Granzyme B: 15.63 pg/ml
样品类型 Serum, plasma and cell culture supernatants.
标准范围 IL8: 1500 - 46.88 pg/ml
IL17: 500 - 15.63 pg/ml
IFN gamma: 500 - 15.63 pg/ml
Granzyme B: 1000 - 31.25 pg/ml
样本量 50 µl
別名 IL17A; Interleukin 17A; IL-17A; IL-17; CTLA8; IL17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Cytotoxic T-Lymphocyte-Associated Protein 8; Cytotoxic T-Lymphocyte-Associated Antigen 8

CXCL8; C-X-C Motif Chemokine Ligand 8; MDNCF; NAP-1; MONAP; GCP-1; Monocyte-Derived Neutrophil Chemotactic Factor; Monocyte-Derived Neutrophil-Activating Peptide; Granulocyte Chemotactic Protein 1; Chemokine (C-X-C Motif) Ligand 8; SCYB8; LYNAP; LUCT; LECT; IL-8; GCP1; NAP1; NAF; IL8; Beta Endothelial Cell-Derived Neutrophil Activating Peptide

IFN gamma: IFNG; Interferon Gamma; Immune Interferon; IFN-Gamma; IMD69; IFG; IFI

Granzyme B: GZMB; Granzyme B; CTSGL1; CGL1; SECT; HLP; T-Cell Serine Protease 1-3E; Cathepsin G-Like 1; CGL-1; CSP-B; CTLA1; CCPI; CSPB; Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1); Cytotoxic T-Lymphocyte Proteinase 2; Cytotoxic Serine Protease B; Human Lymphocyte Protein; Fragmentin 2; EC 3.4.21.79; C11; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Lymphocyte Protease; Fragmentin-2; Granzyme 2; Granzyme-2; EC 3.4.21; CTLA-1; GRB

应用说明

检测时间 ~ 5 hours

属性

形式 96 well
存放说明 Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

基因名称 CXCL8; IL17A; IFNG; GZMB
全名 C-X-C Motif Chemokine Ligand 8
Interleukin 17A
Interferon Gamma
Granzyme B
背景介绍 IL8: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.

IL17: This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.

IFN gamma: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.

Granzyme B: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.
生物功能 IL8: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection.

IL17: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.

IFN gamma: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.

Granzyme B: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse.
产品亮点 Related Product:
IL8 antibodies;
IL17 antibodies;
IFN Gamma;
Granzyme B antibodies;

Related news:
Gamma Delta T cell validation kit is launched.

检测图片 (5) Click the Picture to Zoom In

  • Antibodies Coating Pattern In Microtiter Plate of ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B)

  • ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B)

    ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B) results of a typical standard for Human IL8 alpha run with optical density reading at 450 nm.

  • ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B)

    ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B) results of a typical standard for Human IL17 alpha run with optical density reading at 450 nm.

  • ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B)

    ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B) results of a typical standard for Human IFN-gamma alpha run with optical density reading at 450 nm.

  • ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, granzyme B)

    ARG83110 arigoPLEX® Human Gamma Delta T cell multiplex ELISA Kit (IL8, IL17, IFN-gamma, Granzyme B) results of a typical standard for Human Granzyme B alpha run with optical density reading at 450 nm.

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