ARG52463
anti-Tyrosine Hydroxylase phospho (Ser31) antibody
anti-Tyrosine Hydroxylase phospho (Ser31) antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse,Rat
Cancer antibody; Metabolism antibody; Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Tyrosine Hydroxylase phospho (Ser31) |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | NHuPrm |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Tyrosine Hydroxylase |
| 抗原物种 | Rat |
| 抗原 | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser31 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | DYT14; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; DYT5b; EC 1.14.16.2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~60k tyrosine hydroxylase protein phosphorylated at Ser31. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TH |
| 全名 | tyrosine hydroxylase |
| 背景介绍 | Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs. |
| 产品亮点 | Related Antibody Duos and Panels: ARG30212 Phospho Tyrosine Hydroxylase Antibody Panel (Total, pS31, pS40) Related products: Tyrosine Hydroxylase antibodies; Tyrosine Hydroxylase Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: Astrocyte-to-neuron conversion for Parkinson's disease treatment |
| 研究领域 | Cancer antibody; Metabolism antibody; Neuroscience antibody |
| 预测分子量 | 59 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52463 anti-Tyrosine Hydroxylase phospho (Ser31) antibody WB image
Western blot: PC-12 cells incubated in the absence (Control) and presence of okadaic acid (OA, 1 µM for 60 min) showing specific immunolabeling of the ~60 kDa TH phosphorylated at Ser31 stained with ARG52463 anti-Tyrosine Hydroxylase phospho (Ser31) antibody.
