ARG40777
anti-TTF1 antibody
anti-TTF1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TTF1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TTF1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human TTF1. |
| 偶联标记 | Un-conjugated |
| 別名 | TITF1; NKX2.1; BCH; Thyroid nuclear factor 1; BHC; NKX2A; TTF1; TTF-1; Thyroid transcription factor 1; Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; T/EBP; Thyroid-specific enhancer-binding protein; TEBP; NK-2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 实际分子量 | 39 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NKX2-1 |
| 全名 | NK2 homeobox 1 |
| 背景介绍 | This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014] |
| 生物功能 | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 39 kDa |
| 翻译后修饰 | Phosphorylated on serine residues by STK3/MST2. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG40777 anti-TTF1 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG40777 anti-TTF1 antibody (red). DAPI (blue) for nuclear staining.
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ARG40777 anti-TTF1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human thyroid tissue stained with ARG40777 anti-TTF1 antibody.
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ARG40777 anti-TTF1 antibody WB image
Western blot: 293 cell lysate stained with ARG40777 anti-TTF1 antibody.
