anti-TFE3 antibody [SQab21248]
anti-TFE3 antibody [SQab21248] for IHC-Formalin-fixed paraffin-embedded sections and Human
|产品描述||Recombinant Rabbit Monoclonal antibody [SQab21248] recognizes TFE3|
|抗原||Synthetic peptide of Human TFE3.|
|別名||bHLHe33; TFEA; Class E basic helix-loop-helix protein 33; Transcription factor E3; RCCX1; RCCP2|
|应用说明||IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|纯化||Purification with Protein A.|
|缓冲液||PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.|
|抗菌剂||0.01% Sodium azide|
|稳定剂||40% Glycerol and 0.05% BSA|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|全名||transcription factor binding to IGHM enhancer 3|
|生物功能||Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). [UniProt]|
|翻译后修饰||Sumoylated; does not affect dimerization with MITF. [UniProt]|
检测图片 (1) Click the Picture to Zoom In
ARG66881 anti-TFE3 antibody [SQab21248] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human renal cell carcinoma tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66881 anti-TFE3 antibody [SQab21248] for 30 min at RT.