ARG63539
anti-TEM8 / Anthrax Toxin Receptor 1 antibody
anti-TEM8 / Anthrax Toxin Receptor 1 antibody for ICC/IF and Human
Cell Biology and Cellular Response antibody; Controls and Markers antibody; Microbiology and Infectious Disease antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes TEM8 / Anthrax Toxin Receptor 1 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow, Rat, Dog |
| 应用 | ICC/IF |
| 特异性 | This antibody is expected to recognise variant 1 (NP_115584) only. |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TEM8 / Anthrax Toxin Receptor 1 |
| 抗原物种 | Human |
| 抗原 | C-RAPPPSRPPPRPSV |
| 偶联标记 | Un-conjugated |
| 別名 | Tumor endothelial marker 8; Anthrax toxin receptor 1; ATR; TEM8; GAPO |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] |
| 研究领域 | Cell Biology and Cellular Response antibody; Controls and Markers antibody; Microbiology and Infectious Disease antibody |
| 预测分子量 | 63 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG63539 anti-TEM8 / Anthrax Toxin Receptor 1 antibody ICC/IF image
Immunofluorescence: Paraformaldehyde-fixed HeLa cells permeabilized with 0.15% Triton. Cells were stained with ARG63539 anti-TEM8 / Anthrax Toxin Receptor 1 antibody (green) at 10 µg/ml dilution for 1 hour. DAPI (blue) for nuclear staining. Negative control: Unimmunized goat IgG (green) at 10 µg/ml dilution.
