ARG57846
anti-SMARCC1 antibody
anti-SMARCC1 antibody for Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SMARCC1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SMARCC1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human SMARCC1. |
| 偶联标记 | Un-conjugated |
| 別名 | Rsc8; SRG3; SWI3; BAF155; CRACC1; SWI/SNF complex subunit SMARCC1; BAF155; BRG1-associated factor 155; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex 155 kDa subunit |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | 293T |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SMARCC1 |
| 全名 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 |
| 背景介绍 | The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 123 kDa |
| 翻译后修饰 | Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG57846 anti-SMARCC1 antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG57846 anti-SMARCC1 antibody at 1:1000 dilution.
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ARG57846 anti-SMARCC1 antibody IP image
Immunoprecipitation: 200 µg extracts of 293T cells were immunoprecipitated and stained with ARG57846 anti-SMARCC1 antibody at 1:1000 dilition.
