anti-SARS-CoV Spike protein antibody

anti-SARS-CoV Spike protein antibody for Western blot and Virus

Microbiology and Infectious Disease antibody
publication_link 参考文献1


产品描述 Rabbit Polyclonal antibody recognizes SARS-CoV Spike protein.
反应物种 Virus
应用 WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 SARS-CoV Spike protein
抗原 KLH-conjugated synthetic peptide corresponding to aa. 532-562 of the middle of SARS-CoV Spike protein.
偶联标记 Un-conjugated


应用 推荐稀释比
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


形式 Liquid
纯化 Purification with Protein G.
缓冲液 PBS and 0.09% (W/V) Sodium azide
抗菌剂 0.09% (W/V) Sodium azide
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.


生物功能 S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. [UniProt]
细胞定位 Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly (By similarity). Some S oligomers are transported to the plasma membrane, where they may mediate cell- cell fusion.
产品亮点 Related products:
SARS-CoV antibodies; SARS-CoV ELISA Kits; SARS-CoV recombinant proteins; Anti-Rabbit IgG secondary antibodies;
Related news:
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研究领域 Microbiology and Infectious Disease antibody

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  • ARG54885 anti-SARS-CoV Spike protein antibody WB image

    Western blot: Recombinant Spike proteins (aa. 17-537 or aa. 17-756) stained with ARG54885 anti-SARS-CoV Spike protein antibody.


Assessing the application of a pseudovirus system for emerging SARS-CoV-2 and re-emerging avian influenza virus H5 subtypes in vaccine development.

WB / Virus

Sheng-Wen Huang et al.
Biomed J.,  (2020)