ARG56204
anti-Prolactin Receptor antibody [B6.2]
anti-Prolactin Receptor antibody [B6.2] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [B6.2] recognizes Prolactin Receptor |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B6.2 |
| 同位型 | IgG1, kappa |
| 靶点名称 | Prolactin Receptor |
| 抗原物种 | Human |
| 抗原 | Semi-purified Human Prolactin Receptor. |
| 偶联标记 | Un-conjugated |
| 別名 | MFAB; hPRLrI; PRL-R; Prolactin receptor; HPRL |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRLR |
| 全名 | prolactin receptor |
| 背景介绍 | This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011] |
| 生物功能 | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. [UniProt] |
| 细胞定位 | Cell surface and cytoplasmic |
| 预测分子量 | 70 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG56204 anti-Prolactin Receptor antibody [B6.2] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human testicular carcinoma stained with ARG56204 anti-Prolactin Receptor antibody [B6.2].
