ARG41742
anti-MICAL1 antibody
anti-MICAL1 antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MICAL1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MICAL1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 718-1067 of Human MICAL1 (NP_073602.3). |
| 偶联标记 | Un-conjugated |
| 別名 | MICAL; EC 1.14.13.-; Protein-methionine sulfoxide oxidase MICAL1; NICAL; MICAL-1; NEDD9-interacting protein with calponin homology and LIM domains; Molecule interacting with CasL protein 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | A549 | ||||
| 实际分子量 | ~ 132 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8TDZ2 Human Protein-methionine sulfoxide oxidase MICAL1 Swiss-port # Q8VDP3 Mouse Protein-methionine sulfoxide oxidase MICAL1 |
|---|---|
| 基因名称 | MICAL1 |
| 全名 | microtubule associated monooxygenase, calponin and LIM domain containing 1 |
| 背景介绍 | This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
| 生物功能 | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. [UniProt] |
| 细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton. Midbody. Note=Accumulates transiently at the abscission site before abscission occurs. [UniProt] |
| 预测分子量 | 118 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG41742 anti-MICAL1 antibody WB image
Western blot: 25 µg of A549 cell lysate stained with ARG41742 anti-MICAL1 antibody at 1:1000 dilution.
