ARG40177
anti-IL37 / IL1F7 / FIL1 zeta antibody
anti-IL37 / IL1F7 / FIL1 zeta antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL37 / IL1F7 / FIL1 zeta |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | The antibody is Human specific. Multiple isoforms of IL37 are known to exist. The antibody will only detect the largest isoform. The antibody is predicted to not cross-react with IL36. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL37 / IL1F7 / FIL1 zeta |
| 抗原物种 | Human |
| 抗原 | A 17 amino acid peptide within aa. 30-80 of Human IL37. |
| 偶联标记 | Un-conjugated |
| 別名 | Interleukin-1 zeta; IL-1 zeta; FIL1; Interleukin-37; IL-1X; IL-1F7; FIL1 zeta; IL-1H4; Interleukin-1 homolog 4; FIL1Z; IL1H4; Interleukin-1 family member 7; Interleukin-23; IL-37; FIL1(ZETA); IL-1H; IL-1RP1; IL1RP1; IL1F7; Interleukin-1-related protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human lung and Human kidney | ||||||
| 实际分子量 | 23 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL37 |
| 全名 | interleukin 37 |
| 背景介绍 | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. [UniProt] |
| 细胞定位 | Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). [UniProt] |
| 预测分子量 | 24 kDa |
| 翻译后修饰 | Proteolytically converted to the mature form by CASP1. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG40177 anti-IL37 / IL1F7 / FIL1 zeta antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG40177 anti-IL37 / IL1F7 / FIL1 zeta antibody at 20 µg/ml dilution.
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ARG40177 anti-IL37 / IL1F7 / FIL1 zeta antibody WB image
Western blot: Human lung lysates stained with ARG40177 anti-IL37 / IL1F7 / FIL1 zeta antibody at 1 µg/ml dilution in the absence (left) and the presence (right) of blocking peptide.
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ARG40177 anti-IL37 / IL1F7 / FIL1 zeta antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney tissue stained with ARG40177 anti-IL37 / IL1F7 / FIL1 zeta antibody at 5 µg/ml dilution.
