ARG66086
anti-IL1RA antibody
anti-IL1RA antibody for ELISA,Neutralizing,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL1RA |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, Neut, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL1RA |
| 抗原物种 | Human |
| 抗原 | E. coli derived recombinant Human IL1RA. (MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE) |
| 偶联标记 | Un-conjugated |
| 別名 | IL1 inhibitor; Interleukin-1 receptor antagonist protein; ICIL-1RA; MVCD4; IL1RA; DIRA; IL-1RN; Anakinra; IL1F3; IRAP; IL-1ra; IL-1ra3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.2) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P18510 Human Interleukin-1 receptor antagonist protein |
|---|---|
| 基因名称 | IL1RN |
| 全名 | interleukin 1 receptor antagonist |
| 背景介绍 | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. [UniProt] |
| 预测分子量 | 20 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG66086 anti-IL1RA antibody WB image
Western blot: 250 - 0.24 ng of Human IL-1RA stained with ARG66086 anti-IL1RA antibody, under non-reducing conditions.
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ARG66086 anti-IL1RA antibody standard curve image
Sandwich ELISA: ARG66086 anti-IL1RA antibody as a capture antibody at 0.5 - 2.0 µg/ml combined with ARG66087 anti-IL1RA antibody (Biotin) as a detection antibody. Results of a typical standard run with optical density reading at 405 - 650 nm.
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ARG66086 anti-IL1RA antibody WB image
Western blot: 250 - 0.24 ng of Human IL-1RA stained with ARG66086 anti-IL1RA antibody, under reducing conditions.
