anti-IL1 beta antibody

anti-IL1 beta antibody for ELISA,Functional study,Western blot and Rat

Pyroptosis Study antibody


产品描述 Rabbit Polyclonal antibody recognizes IL1 beta
This antibody recognizes rat IL-1 beta. Interleukin-1β is a 152 amino acid active pro-inflammatory cytokine produced with an additional 116 amino acid pro-peptide region. IL-1β has a broad mode of action, stimulating prostaglandin synthesis, neutrophil, T cell and B cell activation and collagen synthesis.
反应物种 Rat
应用 ELISA, FuncSt, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 IL1 beta
抗原物种 Rat
抗原 Recombinant rat IL-1 beta (PRP23).
偶联标记 Un-conjugated
別名 Interleukin-1 beta; IL1-BETA; IL-1; IL-1 beta; Catabolin; IL1F2


应用 推荐稀释比
ELISA0.25 - 1.0 µg/ml
WB0.1 - 0.2 µg/ml
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


形式 Liquid
纯化 Affinity purification with immunogen.
缓冲液 PBS
浓度 1 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.


基因名称 Il1b
全名 interleukin 1 beta
背景介绍 IL1 beta protein is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
生物功能 IL1 beta is a potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). [UniProt]
产品亮点 Related products:
IL1 beta antibodies; IL1 beta ELISA Kits; IL1 beta Duos / Panels; IL1 beta recombinant proteins; Anti-Rabbit IgG secondary antibodies;
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研究领域 Pyroptosis Study antibody
预测分子量 31 kDa
翻译后修饰 Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.

检测图片 (2) Click the Picture to Zoom In

  • ARG22489 anti-IL1 beta antibody WB image

    Western blot: Conditional media from cultured primary glial cells treated with or without LPS. The blots were stained with ARG22489 anti-IL1 beta antibody at 1:1000 dilution.

  • ARG22489 anti-IL1 beta antibody WB image

    Western blot: Rat spinal cord tissue treated with or without LPC. The blots were stained with ARG22489 anti-IL1 beta antibody at 1:1000 dilution.