anti-IL1 beta antibody [11E5]

anti-IL1 beta antibody [11E5] for ELISA,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections and Human

Pyroptosis Study antibody


产品描述 Mouse Monoclonal antibody [11E5] recognizes IL1 beta
反应物种 Hu
宿主 Mouse
克隆 Monoclonal
克隆号 11E5
同位型 IgG2b
靶点名称 IL1 beta
抗原物种 Human
抗原 recombinant human IL-1, β
偶联标记 Un-conjugated
別名 Interleukin-1 beta; IL1-BETA; IL-1; IL-1 beta; Catabolin; IL1F2


应用 推荐稀释比
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


形式 Liquid
纯化 Protein A affinity purified.
缓冲液 PBS (pH 7.4) and 0.1% Sodium azide
抗菌剂 0.1% Sodium azide
浓度 1.0-2.0 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 3553 Human IL1B

Swiss-port # P01584 Human Interleukin-1 beta

基因名称 IL1B
全名 interleukin 1, beta
背景介绍 IL1 beta protein is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
生物功能 IL1 beta is a potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). [UniProt]
产品亮点 Related products:
IL1 beta antibodies; IL1 beta ELISA Kits; IL1 beta Duos / Panels; IL1 beta recombinant proteins; Anti-Mouse IgG secondary antibodies;
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研究领域 Pyroptosis Study antibody
预测分子量 31 kDa
翻译后修饰 Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.


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