ARG58717
anti-Filamin B antibody
anti-Filamin B antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Filamin B |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Filamin B |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1686-1785 of Human Filamin B (NP_001157789.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Actin-binding-like protein; ABP-280; TAP; ABP-280 homolog; LRS1; Truncated ABP; ABP-278; Fh1; Filamin-B; TABP; AOI; Thyroid autoantigen; FLN-B; FLN1L; Beta-filamin; SCT; Filamin-3; FH1; Filamin homolog 1; Truncated actin-binding protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | A431 | ||||||||
| 实际分子量 | 298 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FLNB |
| 全名 | filamin B, beta |
| 背景介绍 | This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009] |
| 生物功能 | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. [UniProt] |
| 细胞定位 | Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, myofibril, sarcomere, Z line. [UniProt] |
| 预测分子量 | 278 kDa |
| 翻译后修饰 | ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 2 leads to proteasomal degradation which promotes muscle differentiation. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG58717 anti-Filamin B antibody ICC/IF image
Immunofluorescence: HUVEC cells stained with ARG58717 anti-Filamin B antibody at 1:100 dilution.
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ARG58717 anti-Filamin B antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver injury stained with ARG58717 anti-Filamin B antibody at 1:100 dilution.
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ARG58717 anti-Filamin B antibody WB image
Western blot: 25 µg of A431 cell lysate stained with ARG58717 anti-Filamin B antibody at 1:1000 dilution.
