ARG52855
anti-ERBB3 / HER3 antibody
anti-ERBB3 / HER3 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ERBB3 / HER3 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ERBB3 / HER3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from internal region of human c-erbB-3 protein. |
| 偶联标记 | Un-conjugated |
| 別名 | MDA-BF-1; LCCS2; p180-ErbB3; Proto-oncogene-like protein c-ErbB-3; c-erbB3; p85-sErbB3; Tyrosine kinase-type cell surface receptor HER3; p45-sErbB3; erbB3-S; HER3; c-erbB-3; ErbB-3; EC 2.7.10.1; Receptor tyrosine-protein kinase erbB-3 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Incubation Time: 30 min at RT. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | Breast Carcinoma, Colon Carcinoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunogen affinity purified |
| 缓冲液 | PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide |
| 抗菌剂 | < 0.1% Sodium azide |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P21860 Human Receptor tyrosine-protein kinase erbB-3 |
|---|---|
| 背景介绍 | The gene for c-erbB-3/HER-3 is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2kb mRNA which is translated into a 160/180kDa glycoprotein. The c-erbB-3/HER-3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. The c-erbB-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. |
| 细胞定位 | Membrane |
| 研究领域 | Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody |
| 预测分子量 | 148 kDa |
| 翻译后修饰 | Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). |
检测图片 (1) Click the Picture to Zoom In
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ARG52855 anti-ERBB3 / HER3 antibody IHC-P image
Immunohistochemistry: Human Colon Carcinoma stained with ARG52855 anti-ERBB3 / HER3 antibody.
文献引用
HER4 promotes the progression of colorectal cancer by promoting epithelial‑mesenchymal transition.
IHC-P / Human
