ARG65661

anti-Dengue virus NS1 antibody [SQab1502]

anti-Dengue virus NS1 antibody [SQab1502] for ELISA,ICC/IF and Dengue virus

Microbiology and Infectious Disease antibody

概述

产品描述

Mouse Monoclonal antibody [SQab1502] recognizes Dengue virus NS1

反应物种 DEN
应用 ELISA, ICC/IF
特异性 This antibody recognizes monomer, dimer, hexamer of DENV1/2/3/4 NS1 protein.
宿主 Mouse
克隆 Monoclonal
克隆号 SQab1502
同位型 IgG
靶点名称 Dengue virus NS1
抗原物种 Virus
抗原 Recombinant hexamer Dengue virus NS1 protein from drosophila cell
偶联标记 Un-conjugated
全名 Dengue virus nonstructural protein 1
別名 Dengue virus NS1 antibody; Dengue virus nonstructural glycoprotein NS1 antibody

应用说明

应用建议
应用 推荐稀释比
ELISA1:1000 - 1:5000
ICC/IF1:200 - 1:800
应用说明 Recommend using ARG65660 Dengue virus NS1 antibody [SQab1501] for WB, ICC/IF and flow cytrometry studies.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
缓冲液 PBS (pH 7.4) and 0.01% Thimerosal.
抗菌剂 0.01% Thimerosal
浓度 1 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

基因名称 DENV_gp1
基因全名 Dengue virus nonstructural protein 1
背景介绍 Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients' blood samples (up to 50 μg/mL) or infected cell supernatants (various from ng/mL to μg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic.
生物功能 Dengue virus (DENV) non-structural protein 1 (NS1) is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). [provide by uniprot]
产品亮点 Related products:
Dengue Virus antibodies; Dengue Virus ELISA Kits; Dengue Virus Duos / Panels; Anti-Mouse IgG secondary antibodies;
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研究领域 Microbiology and Infectious Disease antibody

检测图片 (2) Click the Picture to Zoom In

  • ARG65661 anti-Dengue virus NS1 antibody [SQab1502] & ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) ELISA image

    ELISA: E. coli expressed recombinant Dengue virus type 1-4 NS1 protein (major in monomer) detected by ARG65661 anti-Dengue virus NS1 antibody [SQab1502] as capture antibody (2.5 μg/ml), and ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) (0.5 μg/ml) as detection antibody, followed by incubation with streptavidin-HRP.

  • ARG65661 anti-Dengue virus NS1 antibody [SQab1502] & ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) ELISA image

    ELISA: 293 cells expressed dengue virus type 2 NS1 protein (major in hexamer) detected by ARG65661 anti-Dengue virus NS1 antibody [SQab1502] as capture antibody (2.5 μg/ml), and ARG65662 anti-Dengue virus NS1 antibody [SQab1503] (Biotin) (0.5 μg/ml) as detection antibody, followed by incubation with streptavidin-HRP.