ARG63527
anti-DUSP16 antibody
anti-DUSP16 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes DUSP16 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog |
| 应用 | IHC-P |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DUSP16 |
| 抗原物种 | Human |
| 抗原 | AHEMIGTQIVTER-C |
| 偶联标记 | Un-conjugated |
| 別名 | MKP-7; Dual specificity protein phosphatase 16; MAP kinase phosphatase 7; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 7; EC 3.1.3.48; MKP7 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9BY84 Human Dual specificity protein phosphatase 16 |
|---|---|
| 背景介绍 | This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 73 kDa |
| 翻译后修饰 | Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity. (Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis. |
检测图片 (1) Click the Picture to Zoom In
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ARG63527 anti-DUSP16 antibody IHC-P image
Immunohistochemistry: paraffin embedded Human Placenta. (Steamed antigen retrieval with citrate buffer pH 6) stained with ARG63527 anti-DUSP16 antibody at 2.5 µg/ml dilution followed by AP-staining.
