ARG41478
anti-Cytochrome P450 2E1 antibody
anti-Cytochrome P450 2E1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Cytochrome P450 2E1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Cytochrome P450 2E1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 234-493 of Human Cytochrome P450 2E1 (NP_000764.1). |
| 偶联标记 | Un-conjugated |
| 別名 | EC 1.14.13.n7; Cytochrome P450 2E1; Cytochrome P450-J; EC 1.14.13.-; P450C2E; CYPIIE1; CYP2E; 4-nitrophenol 2-hydroxylase; P450-J; CPE1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse kidney | ||||||||
| 实际分子量 | 55 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CYP2E1 |
| 全名 | cytochrome P450, family 2, subfamily E, polypeptide 1 |
| 背景介绍 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008] |
| 生物功能 | Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. [UniProt] |
| 细胞定位 | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. [UniProt] |
| 预测分子量 | 57 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG41478 anti-Cytochrome P450 2E1 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG41478 anti-Cytochrome P450 2E1 antibody.
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ARG41478 anti-Cytochrome P450 2E1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver cancer tissue stained with ARG41478 anti-Cytochrome P450 2E1 antibody at 1:100 dilution.
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ARG41478 anti-Cytochrome P450 2E1 antibody WB image
Western blot: 25 µg of Mouse kidney lysate stained with ARG41478 anti-Cytochrome P450 2E1 antibody at 1:1000 dilution.
