ARG67056
anti-ChemR23 / CMKLR1 antibody
anti-ChemR23 / CMKLR1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 反应物种 | Hu |
|---|---|
| 预测物种 | Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ChemR23 / CMKLR1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to Human CMKLR1 . |
| 偶联标记 | Un-conjugated |
| Protein Full name | Chemerin-like receptor 1 |
| 別名 | CMKLR1, Chemerin Chemokine-Like Receptor 1, Chemokine-Like Receptor 1, RVER1, G-Protein Coupled Receptor ChemR23, G-Protein Coupled Receptor DEZ, Chemerin-Like Receptor 1, Resolvin E1 Receptor, Chemerin Receptor, DEZ, Orphan G-Protein Coupled Receptor, Dez, Chemokine Receptor-Like 1, CHEMERINR, ChemR23, CHEMR23 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 阳性对照 | A549 | ||||||||
| 实际分子量 | 42 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CMKLR1 |
| 全名 | Chemerin Chemokine-Like Receptor 1 |
| 背景介绍 | Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] |
| 生物功能 | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis PubMed:27716822. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. [UniProt] |
| 细胞定位 | Cell membrane; Membrane |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG67056 anti-ChemR23 / CMKLR1 antibody IHC-P image
Immunohistochemistry: Human tonsil stained with ARG67056 anti-ChemR23 / CMKLR1 antibody at 1:200 dilution.
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ARG67056 anti-ChemR23 / CMKLR1 antibody ICC/IF image
Immunofluorescence: A549 stained with ARG67056 anti-ChemR23 / CMKLR1 antibody at 1:200 dilution.
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ARG67056 anti-ChemR23 / CMKLR1 antibody WB image
Western blot: 293T stained with ARG67056 anti-ChemR23 / CMKLR1 antibody at 1:1000 dilution.
