ARG59428
anti-CRLF2 antibody
anti-CRLF2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CRLF2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | At least two isoforms of CRLF2 are known to exist; this antibody will recognize both isoforms. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CRLF2 |
| 抗原物种 | Human |
| 抗原 | A 19 amino acid synthetic peptide within aa. 140-190 of Human CRLF2. |
| 偶联标记 | Un-conjugated |
| 別名 | CRL2; Cytokine receptor-like 2; Cytokine receptor-like factor 2; Thymic stromal lymphopoietin protein receptor; TSLP receptor; TSLPR; IL-XR; CRLF2Y |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human liver | ||||||
| 实际分子量 | 53 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CRLF2 |
| 全名 | cytokine receptor-like factor 2 |
| 背景介绍 | This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014] |
| 生物功能 | Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. [UniProt] |
| 细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. [UniProt] |
| 预测分子量 | 42 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG59428 anti-CRLF2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG59428 anti-CRLF2 antibody at 20 µg/ml dilution.
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ARG59428 anti-CRLF2 antibody WB image
Western blot: Human liver lysate stained with ARG59428 anti-CRLF2 antibody at 0.5, 1 and 2 µg/ml dilution.
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ARG59428 anti-CRLF2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG59428 anti-CRLF2 antibody at 5 µg/ml dilution.
