ARG56170
anti-CRHR2 / CRF-R2 antibody
anti-CRHR2 / CRF-R2 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CRHR2 / CRF-R2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CRHR2 / CRF-R2 |
| 抗原物种 | Human |
| 抗原 | A recombinant protein fragment from the N-terminal portion of human CRHR2 / CRF-R2. |
| 偶联标记 | Un-conjugated |
| 別名 | Corticotropin-releasing hormone receptor 2; HM-CRF; CRFR-2; CRF-R2; CRF-R-2; CRH-R-2; Corticotropin-releasing factor receptor 2; CRFR2; CRF2; CRH-R2; CRF-RB |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 0.1 mg/ml BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CRHR2 |
| 全名 | corticotropin releasing hormone receptor 2 |
| 背景介绍 | The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] |
| 生物功能 | G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. [UniProt] |
| 细胞定位 | Membrane, Secreted |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | A N-glycosylation site within the signal peptide impedes its proper cleavage and function. |
检测图片 (1) Click the Picture to Zoom In
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ARG56170 anti-CRHR2 / CRF-R2 antibody WB image
Western blot: T98G cell lysate stained with ARG56170 anti-CRHR2 / CRF-R2 antibody at 0.5 µg/ml dilution.
