ARG58407

anti-CLN5 antibody

anti-CLN5 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

概述

产品描述 Rabbit Polyclonal antibody recognizes CLN5
反应物种 Hu, Ms, Rat
应用 IHC-P, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 CLN5
抗原物种 Human
抗原 Recombinant fusion protein corresponding to aa. 96-407 of Human CLN5 (NP_006484.1).
偶联标记 Un-conjugated
別名 NCL; Protein CLN5; Ceroid-lipofuscinosis neuronal protein 5

应用说明

应用建议
应用 推荐稀释比
IHC-P1:50 - 1:100
WB1:500 - 1:1000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Mouse heart
实际分子量 50 kDa

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 1203 Human CLN5

GeneID: 211286 Mouse CLN5

Swiss-port # O75503 Human Ceroid-lipofuscinosis neuronal protein 5

Swiss-port # Q3UMW8 Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog

基因名称 CLN5
全名 ceroid-lipofuscinosis, neuronal 5
背景介绍 This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.[provided by RefSeq, Oct 2008]
细胞定位 Lysosome. [UniProt]
预测分子量 41 kDa
翻译后修饰 N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes.

Ceroid-lipofuscinosis neuronal protein 5: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5, secreted form) (PubMed:24038957, PubMed:20052765).

Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end (PubMed:26342652). [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG58407 anti-CLN5 antibody WB image

    Western blot: 25 µg of Mouse heart lysate stained with ARG58407 anti-CLN5 antibody at 1:3000 dilution.