ARG42422
anti-CD300a + CD300c antibody [MEM-260] (APC)
anti-CD300a + CD300c antibody [MEM-260] (APC) for Flow cytometry and Human
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [MEM-260] recognizes CD300a + CD300c |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The antibody MEM-260 reacts with an extracellular epitope of CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-260 |
| 同位型 | IgG1 |
| 靶点名称 | CD300a + CD300c |
| 抗原物种 | Human |
| 抗原 | HPB Human acute lymphoid leukemia cell line. |
| 偶联标记 | APC |
| 別名 | CMRF-35-H9; Inhibitory receptor protein 60; NK inhibitory receptor; CMRF35-H; CMRF35H9; CD antigen CD300a; IRC1/IRC2; IGSF12; CMRF35H; IRp60; IgSF12; CMRF35-like molecule 8; CMRF35-H9; CMRF-35H; CD300 antigen-like family member A; CLM-8; IRC1; IRC2; Immunoglobulin superfamily member 12 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD300A |
| 全名 | CD300a molecule |
| 背景介绍 | This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| 生物功能 | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine. N-glycosylated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42422 anti-CD300a + CD300c antibody [MEM-260] (APC) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG42422 anti-CD300a + CD300c antibody [MEM-260] (APC).
