anti-CD11c antibody [N418]
anti-CD11c antibody [N418] for IHC-Frozen sections,Flow cytometry,ICC/IF,Immunoprecipitation and Mouse
|产品描述||Hamster Monoclonal antibody [N418] recognizes CD11c.
Hamster anti Mouse CD11c antibody, clone N418 recognizes the murine homolog of human CD11c, a 150/90 kDa member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells.Hamster anti Mouse CD11c antibody, clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo (Wang et al. 2000).
|应用||FACS, ICC/IF, IHC-Fr, IP|
|抗原||Mouse spleen dendritic cells.|
|全名||integrin, alpha X (complement component 3 receptor 4 subunit)|
|別名||CD antigen CD11c; Leu M5; CD11C; SLEB6; Integrin alpha-X; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11 antigen-like family member C|
|应用说明||FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|纯化||Purification with Protein A.|
|缓冲液||PBS and 0.09% Sodium azide.|
|抗菌剂||0.09% Sodium azide|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
|基因全名||integrin, alpha X (complement component 3 receptor 4 subunit)|
|背景介绍||This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]|
|生物功能||Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [UniProt]|