ARG22000

anti-CD11b antibody [M1/70]

anti-CD11b antibody [M1/70] for Flow cytometry,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Immunoprecipitation,Blocking and Mouse,Human,Rhesus Monkey,Baboon

概述

产品描述 Rat Monoclonal antibody [M1/70] recognizes CD11b
反应物种 Hu, Ms, Bb, R. Mk
应用 BL, FACS, ICC/IF, IHC-Fr, IHC-P, IP
特异性 Mouse/Human/Rhesus/Baboon CD11b
宿主 Rat
克隆 Monoclonal
克隆号 M1/70
同位型 IgG2bκ
靶点名称 CD11b
抗原物种 Mouse
抗原 C57BL/10 Mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes
偶联标记 Un-conjugated
全名 integrin, alpha M (complement component 3 receptor 3 subunit)
別名 MAC1A; CR3A; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Integrin alpha-M; MAC-1; CD11 antigen-like family member B; Leukocyte adhesion receptor MO1; MO1A; SLEB6; Neutrophil adherence receptor; CD antigen CD11b; CD11B

应用说明

应用建议
应用 推荐稀释比
BLAssay-dependent
FACS< 1 µg/10^6 cells
ICC/IFAssay-dependent
IHC-FrAssay-dependent
IHC-PAssay-dependent
IPAssay-dependent
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
缓冲液 BBS (pH 8.2)
浓度 0.5 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 16409 Mouse ITGAM

GeneID: 3684 Human ITGAM

Swiss-port # P11215 Human Integrin alpha-M

基因名称 ITGAM
基因全名 integrin, alpha M (complement component 3 receptor 3 subunit)
背景介绍 This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
生物功能 Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. [UniProt]