ARG54260

anti-CD11b antibody [ICRF44] (PE)

anti-CD11b antibody [ICRF44] (PE) for Blocking,Flow cytometry,ICC/IF,IHC-Frozen sections,Western blot and Human,Baboon,Chimpanzee,Pig,Rhesus Monkey

MDSC Marker antibody; Myeloid-derived suppressor cell antibody

概述

产品描述 PE-conjugated Mouse Monoclonal antibody [ICRF44] recognizes CD11b
反应物种 Hu, Bb, Chimp, Pig, R. Mk
应用 BL, FACS, ICC/IF, IHC-Fr, WB
宿主 Mouse
克隆 Monoclonal
克隆号 ICRF44
同位型 IgG1, kappa
靶点名称 CD11b
抗原物种 Human
抗原 Rheumatoid synovial cells and human monocytes
偶联标记 PE
全名 integrin, alpha M (complement component 3 receptor 3 subunit)
別名 MAC1A; CR3A; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Integrin alpha-M; MAC-1; CD11 antigen-like family member B; Leukocyte adhesion receptor MO1; MO1A; SLEB6; Neutrophil adherence receptor; CD antigen CD11b; CD11B

应用说明

应用建议
应用 推荐稀释比
BLAssay-dependent
FACS10 µl/10^6 cells
ICC/IFAssay-dependent
IHC-FrAssay-dependent
WBAssay-dependent
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
预测分子量 127 kDa

属性

形式 Liquid
缓冲液 PBS, Sodium azide and Sucrose
抗菌剂 Sodium azide
稳定剂 Sucrose
存放说明 Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 3684 Human ITGAM

Swiss-port # P11215 Human Integrin alpha-M

基因名称 ITGAM
基因全名 integrin, alpha M (complement component 3 receptor 3 subunit)
背景介绍 CD11b (integrin alpha M chain): Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
生物功能 CD11b: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. [UniProt]
产品亮点 Related products:
CD11b antibodies; CD11b Duos / Panels; Anti-Mouse IgG secondary antibodies;
Related news:
New antibody panels and duos for Tumor immune microenvironment
研究领域 MDSC Marker antibody; Myeloid-derived suppressor cell antibody

检测图片 (3) Click the Picture to Zoom In

  • ARG54260 anti-CD11b antibody [ICRF44] (PE) FACS image

    Flow Cytometry: Human peripheral blood lymphocytes stained with ARG54260 anti-CD11b antibody [ICRF44] (PE) and ARG21335 anti-CD14 antibody [61D3] (FITC).

  • ARG54260 anti-CD11b antibody [ICRF44] (PE) FACS image

    Flow Cytometry: Human peripheral blood lymphocytes stained with ARG54260 anti-CD11b antibody [ICRF44] (PE) and ARG21335 anti-CD14 antibody [61D3] (FITC).

  • ARG54260 anti-CD11b antibody [ICRF44] (PE) FACS image

    Flow Cytometry: Human peripheral blood granulocytes stained with ARG54260 anti-CD11b antibody [ICRF44] (PE).

克隆号文献

Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma.

IHC-Fr / Human

Zenkel M et al.
Am J Pathol.,  (2010)

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Promotion of neutrophil chemotaxis through differential regulation of beta 1 and beta 2 integrins.

BL / Human

Harler MB et al.
J Immunol.,  (1999)

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