概述

产品描述	Rabbit Polyclonal antibody recognizes BRIP1
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	BRIP1
抗原物种	Human
抗原	Recombinant Protein of Human BRIP1.
偶联标记	Un-conjugated
別名	BRCA1-interacting protein C-terminal helicase 1; ATP-dependent RNA helicase BRIP1; OF; BACH1; BRCA1-interacting protein 1; EC 3.6.4.13; Protein FACJ; BRCA1-associated C-terminal helicase 1; FANCJ; Fanconi anemia group J protein

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Mouse liver

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 83990 Human BRIP1 Swiss-port # Q9BX63 Human Fanconi anemia group J protein
基因名称	BRIP1
全名	BRCA1 interacting protein C-terminal helicase 1
背景介绍	The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
生物功能	DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. [UniProt]
预测分子量	141 kDa
翻译后修饰	Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated. Acetylation at Lys-1249 facilitates DNA end processing required for repair and checkpoint signaling.

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