ARG40590
anti-AGTR1 / AT1 antibody
anti-AGTR1 / AT1 antibody for Western blot and Human,Mouse,Rat
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes AGTR1 / AT1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | AGTR1 / AT1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human AGTR1. |
| 偶联标记 | Un-conjugated |
| 別名 | AT1AR; Angiotensin II type-1 receptor; AT1R; Type-1 angiotensin II receptor; AT1BR; AG2S; AT2R1; HAT1R; AT1; AGTR1B; AT1B |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | AGTR1 |
| 全名 | angiotensin II receptor, type 1 |
| 背景介绍 | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012] |
| 生物功能 | Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 41 kDa |
| 翻译后修饰 | C-terminal Ser or Thr residues may be phosphorylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG40590 anti-AGTR1 / AT1 antibody WB image
Western blot: PC-12 cell lysate stained with ARG40590 anti-AGTR1 / AT1 antibody.
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ARG40590 anti-AGTR1 / AT1 antibody WB image
Western blot: Human thoracic aorta stained with ARG40590 anti-AGTR1 / AT1 antibody.
From Qiang Wu et al. Pre-Print (2024), doi: 10.26599/FSHW.2024.9250032, Fig. 5. K.
文献引用
Discovery and mechanism of anti-hypertensive effect of a novel tripeptide (SYP) from medicinal fungus Ganoderma lingzhi
WB / Human
