ARG42215
anti-ADAM22 antibody
anti-ADAM22 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ADAM22 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ADAM22 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 223-400 of Human ADAM22 (NP_004185.1). |
| 偶联标记 | Un-conjugated |
| 別名 | MDC2; Disintegrin and metalloproteinase domain-containing protein 22; ADAM 22; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; Metalloproteinase-disintegrin ADAM22-3 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat kidney | ||||
| 实际分子量 | ~ 100kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9P0K1 Human Disintegrin and metalloproteinase domain-containing protein 22 Swiss-port # Q9R1V6 Mouse Disintegrin and metalloproteinase domain-containing protein 22 |
|---|---|
| 基因名称 | ADAM22 |
| 全名 | ADAM metallopeptidase domain 22 |
| 背景介绍 | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. [provided by RefSeq, Dec 2010] |
| 生物功能 | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. Cell projection, axon. [UniProt] |
| 预测分子量 | 100 kDa |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42215 anti-ADAM22 antibody WB image
Western blot: 25 µg of Rat kidney lysate stained with ARG42215 anti-ADAM22 antibody at 1:1000 dilution.
