ARG43434
anti-ADAM12 antibody
anti-ADAM12 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ADAM12 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ADAM12 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 589-738 of Human ADAM12 (NP_067673.2). |
| 偶联标记 | Un-conjugated |
| 別名 | MCMP; ADAM 12; MCMPMltna; EC 3.4.24.-; Disintegrin and metalloproteinase domain-containing protein 12; Meltrin-alpha; MLTN; MLTNA; CAR10; ADAM12-OT1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse fat | ||||||||
| 实际分子量 | ~ 100 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O43184 Human Disintegrin and metalloproteinase domain-containing protein 12 Swiss-port # Q61824 Mouse Disintegrin and metalloproteinase domain-containing protein 12 |
|---|---|
| 基因名称 | ADAM12 |
| 全名 | ADAM metallopeptidase domain 12 |
| 背景介绍 | This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014] |
| 生物功能 | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). [UniProt] |
| 细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. [UniProt] |
| 预测分子量 | 100 kDa |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG43434 anti-ADAM12 antibody ICC/IF image
Immunofluorescence: NIH/3T3 cells stained with ARG43434 anti-ADAM12 antibody at 1:100 dilution.
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ARG43434 anti-ADAM12 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat heart tissue stained with ARG43434 anti-ADAM12 antibody at 1:100 dilution.
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ARG43434 anti-ADAM12 antibody WB image
Western blot: 25 µg of Mouse fat lysate stained with ARG43434 anti-ADAM12 antibody at 1:1000 dilution.
