ARG30094
Phospho Beclin Antibody Duo (pS234, pS295)
Cancer antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody; Microbiology and Infectious Disease antibody
内含物
| 货号 | 内含物名称 | 宿主克隆性 | 反应 | 应用 | 包装 |
|---|---|---|---|---|---|
| ARG52234 | anti-Beclin 1 phospho (Ser234) antibody | Rabbit pAb | Hu | WB | 50 μl |
| ARG52235 | anti-Beclin 1 phospho (Ser295) antibody | Rabbit pAb | Hu | WB | 50 μl |
概述
| 产品描述 | Autophagy is an essential process that consists of selective degradation of cellular components especially during cell stress and cell cycle extinguishment. Beclin1, as a key molecule in controlling autophagy pathway, can activate both cell survival and cell death pathway through its interaction with different partners. Beclin pSer234 has been shown to interact with 14-3-3 proteins through AKT-mediated phosphorylations. Since phosphorylation of Beclin1 at Ser234 and Ser295 results in autophagy inhibition and oncogenesis, this PTM duo is useful for the detailed study of Beclin1 function as well as its potential in cancer gene therapy. |
|---|---|
| 靶点名称 | Beclin |
| 別名 | Phospho Beclin antibody; Beclin 1 phospho (Ser234) antibody; Beclin 1 phospho (Ser295) antibody |
属性
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 全名 | Antibody Duo for Phospho Beclin (pS234, pS295) |
|---|---|
| 研究领域 | Cancer antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody; Microbiology and Infectious Disease antibody |
检测图片 (2) Click the Picture to Zoom In
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ARG52234 anti-Beclin1 phospho (Ser234) antibody WB image
Western Blot: beclin-1 expressed stained with Beclin1 (phospho Ser234) antibody (ARG52234) at 1: 250 dilution in HeLa cells showing specific immunolabeling of beclin-1 in wild-type (WT), in addition, this immunolabeling is decreased in the beclin-1 double alanine substitution mutant (S234A, S295A) samples.
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ARG52235 anti-Beclin1 phospho (Ser295) antibody WB image
Western Blot: beclin-1 expressed stained with Beclin1 (phospho Ser295) antibody (ARG52235) at 1: 250 dilution in HeLa cells showing specific immunolabeling of beclin-1 in wild-type (WT), in addition, this immunolabeling is eliminated in the beclin-1 alanine substitution mutant (S295A) samples.
