ARG52234
anti-Beclin 1 phospho (Ser234) antibody
anti-Beclin 1 phospho (Ser234) antibody for Western blot and Human
Cancer antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody; Microbiology and Infectious Disease antibody; Autophagy Study antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Beclin 1 phospho (Ser234) |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Bov, Dog, NHuPrm, Sheep |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Beclin 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser234 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | BECN1; Beclin 1; VPS30; ATG6; Coiled-Coil Myosin-Like BCL2-Interacting Protein; Beclin 1, Autophagy Related; Beclin-1; Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein); Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein); ATG6 Autophagy Related 6 Homolog (S. Cerevisiae); Testis Secretory Sperm-Binding Protein Li 215e; ATG6 Autophagy Related 6 Homolog; Beclin1-Gamma; Protein GT197; Beclin1-Beta; Beclin1; GT197 |
应用说明
| 应用建议 |
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| 应用说明 | Specific for the ~60k beclin1 protein phosphorylated at Ser 234. Immunolabeling of the beclin-1 band is decreased in the beclin-1 alanine substitution mutant. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BECN1 |
| 全名 | beclin 1, autophagy related |
| 背景介绍 | This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| 生物功能 | Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense. [UniProt] |
| 细胞定位 | Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Nucleus. [UniProt] |
| 产品亮点 | Related products: Beclin 1 antibodies; Beclin 1 Duos / Panels; |
| 研究领域 | Cancer antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody; Microbiology and Infectious Disease antibody; Autophagy Study antibody |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG52234 anti-Beclin 1 phospho (Ser234) antibody WB image
Western blot: beclin-1 expressed stained with ARG52234 anti-Beclin 1 phospho (Ser234) antibody at 1: 250 dilution in HeLa cells showing specific immunolabeling of beclin-1 in wild-type (WT), in addition, this immunolabeling is decreased in the beclin-1 double alanine substitution mutant (S234A, S295A) samples.
