ARG70358
Dengue virus NS1 recombinant protein (His-tagged, C-ter)
Dengue virus NS1 recombinant protein (His-tagged, C-ter) for SDS-PAGE
Microbiology and Infectious Disease antibody
概述
| 产品描述 | HEK293 cell expressed, His-tagged (C-ter) Dengue virus NS1 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | Dengue virus NS1 protein |
| 物种 | Virus |
| A.A. 序列 | Asp776 - Ala1127 |
| 表达系统 | HEK293 cell |
| Protein Full name | Dengue virus nonstructural protein 1 |
| 別名 | Dengue virus NS1 protein; Dengue virus nonstructural glycoprotein NS1 protein |
属性
| 形式 | Powder |
|---|---|
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not <200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C and -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | DENV_gp1 |
|---|---|
| 全名 | Dengue virus nonstructural protein 1 |
| 背景介绍 | Dengue virus NS1 protein is a nonstructural protein which could be secreted and have been developed as diagnostic biomarker for early detection. There are several forms of NS1 including monomer, dimer, and hexamer during infection. Dimeric NS1 can be anchored to cell membranes with glycosyl-phosphatidylinositol (GPI). Hexameric NS1 can be secreted and detected in patients' blood samples (up to 50 μg/mL) or infected cell supernatants (various from ng/mL to μg/mL depend on serotypes and strains). Studies have shown that NS1 could interfere complement activity and prothrombin activation. In addition, NS1 could elicit antibodies which cross-react with host antigens including coagulation factors and molecules expressed in endothelial cells and platelets through molecular mimic. |
| 生物功能 | Dengue virus (DENV) non-structural protein 1 (NS1) is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome. [Uniprot] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30252 Dengue virus NS1 ELISA Antibody Duo Related products: Dengue virus antibodies; Dengue virus ELISA Kits; Dengue virus Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: New Dengue Virus NS1 antibodies and Antibody Duo Fighting fire with fire: Genetically-engineered mosquitoes as an alternative to fight diseases Tools for studying Dengue Virus Exploring Antiviral Immune Response |
| 研究领域 | Microbiology and Infectious Disease antibody |
