Adrenergic signaling promotes M2 polarization and bone healing

Adrenergic signaling promotes M2 polarization and bone healing



Traumatic brain injury (TBI) accelerates fracture healing, but the underlying mechanism remains unclear. In a recent article published in journal Signal Transduct Target Ther (IF 39.3), Liu et al. reported that TBI stimulates sympathetic tone-mediated bone marrow myelopoiesis via adrenergic signaling to favor fracture healing. In addition, they found that TBI-induced adrenergic signaling promotes M2 polarization of macrophages to shape the anti-inflammation environment in the bone marrow, thus accelerate bone healing process. These results implicate that adrenergic signals could serve as potential targets for fracture healing therapies.

arigo is proud that our Noradrenaline ELISA Kit (ARG80475) was used to demonstrate that TBI significantly stimulated the secretion of norepinephrine ​in patients suffered from fracture subjected to TBI and mice with TBI.


Noradrenaline ELISA Kit (ARG80475)

  • Reactivity: Hu, Ms, Rat
  • Sample: Biological samples
  • Sensitivity: 1.3 pg/ml




More ELISA kits for Monoamines & amino acid

ELISA Kit Human Mouse & Rat
Epinephrine (E) ARG80442 ARG80445
Norepinephrine (NE) ARG80472 ARG80475
Dopamine (DA) ARG80447 ARG80450
2 CAT - E & NE ARG80431  
3 CAT - E, NE & DA ARG80437 ARG80440
Metanephrine (MN)

ARG82792 (urine)
ARG82789 (plasma)

2 MET – MN & NMN

ARG82794 (urine)
ARG82791 (plasma)

Glutamate ARG80453 ARG80453
GABA ARG82788  
Histamine ARG80455 ARG80459
Melatonin ARG82780 ARG80461
Serotonin ARG80480 ARG80482
5-HIAA ARG80441