ARG83782
arigoQIK® Human ULBP1 ELISA Development Kit
arigoQIK® Human ULBP1 ELISA Development 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG83782 arigoQIK® Human ULBP1 ELISA Development Kit, includes Capture antibody, Detection antibody, Standard, and HRP-Streptavidin Solution. This ELISA Development Kit is designed for the development of sandwich ELISA to measure Human ULBP1 in Serum, plasma and cell culture supernatants. For other reagents required for arigoQIK® ELISA Development Kit, please refer ARG83524 Integral Reagent Kit (ELISA Development Kit) More aboutarigoQIK® : ● Optimized capture and detection antibody pairs ● Reduced incubation time and wash cycles ● 2-hour quicker than conventional ELISA process ● 5- and 15-plate packages available |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | ULBP1 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 2 pg/mL |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 3.91-250 pg/mL |
| 样本量 | 50 μL |
| 精确 | Intra-Assay CV: < 10% Inter-Assay CV: < 10% |
| 別名 | UL16-binding protein 1; Retinoic acid early transcript 1I; RAET1I; N2DL-1; NKG2DL1; NKG2D ligand 1; ALCAN-beta |
属性
| 存放说明 | Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
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| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
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| 基因名称 | ULBP1 |
| 全名 | UL16 binding protein 1 |
| 背景介绍 | The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| 生物功能 | Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. [UniProt] |
| 细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. [UniProt] |
| 产品亮点 | Related news: arigoQIK, DIY your sandwich ELISA kits; |
| Title | Download Link |
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| ARG83782 arigoQIK® Human ULBP1 ELISA Development Kit User Manual |
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