ARG83768
arigoQIK® Human TNFRSF11B / OPG ELISA Development Kit
arigoQIK® Human TNFRSF11B / OPG ELISA Development 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG83768 arigoQIK® Human TNFRSF11B / OPG ELISA Development Kit, includes Capture antibody, Detection antibody, Standard, and HRP-Streptavidin Solution. This ELISA Development Kit is designed for the development of sandwich ELISA to measure Human TNFRSF11B / OPG in Serum, plasma and cell culture supernatants. For other reagents required for arigoQIK® ELISA Development Kit, please refer ARG83524 Integral Reagent Kit (ELISA Development Kit) More aboutarigoQIK® : ● Optimized capture and detection antibody pairs ● Reduced incubation time and wash cycles ● 2-hour quicker than conventional ELISA process ● 5- and 15-plate packages available |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | TNFRSF11B / OPG |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 15.63 pg/mL |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 31.25-2000 pg/mL |
| 样本量 | 50 μL |
| 精确 | Intra-Assay CV: < 10% Inter-Assay CV: < 10% |
| 別名 | TNFRSF11B, TNF Receptor Superfamily Member 11b, OCIF, Osteoclastogenesis Inhibitory Factor, Osteoprotegerin, TR1, OPG, Tumor Necrosis Factor Receptor Superfamily, Member 11b, Tumor Necrosis Factor Receptor Superfamily Member 11B, PDB5 |
属性
| 存放说明 | Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
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| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00300 Human Tumor necrosis factor receptor superfamily member 11B |
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| 基因名称 | TNFRSF11B |
| 全名 | TNF Receptor Superfamily Member 11b |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. [UniProt] |
| 产品亮点 | Related news: arigoQIK, DIY your sandwich ELISA kits; |
| 翻译后修饰 | N-glycosylated. Contains sialic acid residues. The N-terminus is blocked. [UniProt] |
| Title | Download Link |
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| ARG83768 arigoQIK® Human TNFRSF11B / OPG ELISA Development Kit User Manual |
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