ARG83780
arigoQIK® Human TNF Receptor II ELISA Development Kit
arigoQIK® Human TNF Receptor II ELISA Development 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG83780 arigoQIK® Human TNF Receptor II ELISA Development Kit, includes Capture antibody, Detection antibody, Standard, and HRP-Streptavidin Solution. This ELISA Development Kit is designed for the development of sandwich ELISA to measure Human TNF Receptor II in Serum, plasma and cell culture supernatants. For other reagents required for arigoQIK® ELISA Development Kit, please refer ARG83524 Integral Reagent Kit (ELISA Development Kit) More aboutarigoQIK® : ● Optimized capture and detection antibody pairs ● Reduced incubation time and wash cycles ● 2-hour quicker than conventional ELISA process ● 5- and 15-plate packages available |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | TNF Receptor II |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 8 pg/mL |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 15.63-1000 pg/mL |
| 样本量 | 50 μL |
| 精确 | Intra-Assay CV: < 10% Inter-Assay CV: < 10% |
| 別名 | TNFR1B; CD antigen CD120b; p75; CD120b; p75TNFR; TNF-R-II; TNFBR; TBPII; TNFR80; TBP-2; TNFR2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; Etanercept; Tumor necrosis factor receptor superfamily member 1B; TNFR-II; TNF-R75; TNF-R2; TNF-RII; p80 TNF-alpha receptor |
属性
| 存放说明 | Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
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| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P20333 Human Tumor necrosis factor receptor superfamily member 1B |
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| 基因名称 | TNFRSF1B |
| 全名 | tumor necrosis factor receptor superfamily, member 1B |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. [UniProt] |
| 产品亮点 | Related news: arigoQIK, DIY your sandwich ELISA kits; |
| 翻译后修饰 | Phosphorylated; mainly on serine residues and with a very low level on threonine residues. A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. [UniProt] |
| Title | Download Link |
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| ARG83780 arigoQIK® Human TNF Receptor II ELISA Development Kit User Manual |
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