ARG54563
anti-vWF antibody [VW92-3]
anti-vWF antibody [VW92-3] for Indirect ELISA,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody
概述
| 产品描述 | Mouse Monoclonal antibody [VW92-3] recognizes vWF |
|---|---|
| 反应物种 | Hu |
| 不反应物种 | Cow |
| 应用 | I-ELISA, IHC-Fr, IHC-P, WB |
| 特异性 | This antibody specifically recognizes human von Willebrand Factor V8 Protease Fragment III (N-terminal trypsin and plasmin sensitive region). This antibody does not inhibit the binding of vWF to the vitronectin receptor. This antibody does not react with bovine vWF. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | VW92-3 |
| 同位型 | IgG2a |
| 靶点名称 | vWF |
| 抗原物种 | Human |
| 抗原 | Human plasma von Willebrand Factor. |
| 抗原表位 | V8 Protease Fragment III; N-termini Trypsin and Plasmin sensitive region. |
| 偶联标记 | Un-conjugated |
| 別名 | VWD; von Willebrand factor; vWF; von Willebrand antigen II; F8VWF |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | 10mM PBS (pH 7.4), 1% BSA |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | VWF |
| 全名 | von Willebrand factor |
| 背景介绍 | The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] |
| 生物功能 | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. [UniProt] |
| 细胞定位 | Secreted |
| 产品亮点 | VWF (Von Willebrand Factor) is a Protein Coding gene. Diseases associated with VWF include von willebrand's disease and von willebrand disease, type 1. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and protein N-terminus binding. An important paralog of this gene is OTOGL. [Supplied by GeneCards] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody |
| 预测分子量 | 309 kDa |
| 翻译后修饰 | All cysteine residues are involved in intrachain or interchain disulfide bonds. N- and O-glycosylated. |
