ARG45489
anti-uPAR antibody
anti-uPAR antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes uPAR |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | uPAR |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to C-terminal region of human uPAR. |
| 偶联标记 | Un-conjugated |
| 別名 | Monocyte activation antigen Mo3; CD antigen CD87; uPAR; U-PAR; URKR; Urokinase plasminogen activator surface receptor; UPAR; CD87 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 45 - 55 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q03405 Human Urokinase plasminogen activator surface receptor |
|---|---|
| 基因名称 | PLAUR |
| 全名 | plasminogen activator, urokinase receptor |
| 背景介绍 | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. [UniProt] |
| 细胞定位 | Cell membrane; Cell projection; invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-; integrin- and vitronectin-dependent manner. Isoform 1: Cell membrane; Lipid-anchor; GPI-anchor. Isoform 2: Secreted. [UniProt]. [UniProt] |
| 预测分子量 | 37 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG45489 anti-uPAR antibody IHC-P image
Immunohistochemistry: Human glioma stained with ARG45489 anti-uPAR antibody at 2 μg/ml dilution.
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ARG45489 anti-uPAR antibody WB image
Western blot: Hela stained with ARG45489 anti-uPAR antibody at 0.5 μg/ml dilution.
